Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats

Pacifico, Ana Miriã; Batista, Samuel P.; Ribeiro, Fernanda Teixeira; Santos, Pedro B. dos; Silveira, Gabriel Bruno; Nascimento, Bruna Pascarelli Pedrico do; Dias, Eduardo Mário; Barbosa, Geraldo; Ribeiro, Miriam O.; Silva, Sérgio Gomes da; Cysneiros, Roberta Monterazzo

doi:10.1016/j.dib.2020.105819

Cited by 2 publications

(7 citation statements)

References 14 publications

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“…This important finding allows us to speculate that the lack of the JZL-195 effect in the experimental group may be related to disrupted OT signaling. Our group recently reported in this model a reduction in OTR expression in the hippocampus concomitantly with an enhancement of OT in the hypothalamus (Pacífico et al, 2020 ). Sun et al ( 1996 ) also noticed an oxytocin and vasopressin elevation in rat hypothalamus following kainic acid-induced seizures.…”

Section: Discussionmentioning

confidence: 78%

“…As the evaluation of the long-term effect of early life seizures in clinical studies is difficult due to the number of variables involved in the outcome, the experimental model in rodents has been used for this purpose. Indeed, rodents of both genders subjected to early-life seizures exhibit a high-functioning autism-like phenotype, as chronic sociability abnormalities revealed by a deficit in social play behavior, low social preference for novelty and discrimination, elevated emotionality/anxiety-related behavior, impaired ultrasonic vocalization, and mild or no cognitive deficit depending on the task demand (Castelhano et al, 2010 , 2013 , 2015 ; Lugo et al, 2014 ; Bernard and Benke, 2015 ; Leite et al, 2016 ; Reynolds et al, 2016 , 2017 ; Barbosa et al, 2017 ; Hodges et al, 2019 ; Mikulecká et al, 2019 ; Pacífico et al, 2020 ). Despite the well documented behavioral dysfunction, the mechanism underlying the impaired sociability remains unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Despite the well documented behavioral dysfunction, the mechanism underlying the impaired sociability remains unknown. Recently, we demonstrated that pilocarpine-induced neonatal status epilepticus (SE) leads to social motivation impairment, reduction in oxytocin receptor (OTR) expression in hippocampus concomitantly with an enhancement of oxytocin in hypothalamus (Pacífico et al, 2020 ). Mouchati et al ( 2019 ) reported increased hyperconnectivity within the hippocampus (CA3–CA1) and between the hippocampus and PFC during the awake and sleep states as involved in impaired sociability.…”

Section: Introductionmentioning

confidence: 99%

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Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

Ribeiro

Serro-Azul

Lorena

et al. 2020

Front. Behav. Neurosci.

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The early life status epilepticus (SE) causes high anxiety and chronic socialization abnormalities, revealed by a low preference for social novelty and deficit in social discrimination. This study investigated the involvement of the endocannabinoid system on the sociability in this model, due to its role in social motivation regulation. Male Wistar rats at postnatal day 9 were subjected to pilocarpine-induced neonatal SE and controls received saline. From P60 the groups received vehicle or JZL195 2 h before each behavioral test to increase endocannabinoids availability. In the sociability test, animals subjected to neonatal SE exhibited impaired sociability, characterized by social discrimination deficit, which was unaffected by the JZL195 treatment. In contrast, JZL195-treated control rats showed low sociability and impaired social discrimination. The negative impact of JZL195 over the sociability in control rats and the lack of effect in animals subjected to neonatal SE was confirmed in the social memory paradigm. In this paradigm, as expected for vehicle-treated control rats, the investigation toward the same social stimulus decreased with the sequential exposition and increased toward a novel stimulus. In animals subjected to neonatal SE, regardless of the treatment, as well as in JZL195-treated control rats, the investigation toward the same social stimulus was significantly reduced with no improvement toward a novel stimulus. Concerning the locomotion, the JZL195 increased it only in control rats. After behavioral tests, brain tissues of untreated animals were used for CB1 receptor quantification by Elisa and for gene expression by RT-PCR: no difference between control and experimental animals was noticed. The results reinforce the evidence that the early SE causes chronic socialization abnormalities, revealed by the low social interest for novelty and impaired social discrimination. The dual FAAH/MAGL inhibitor (JZL195) administration before the social encounter impaired the social interaction in intact rats with no effect in animals subjected to early-life seizures.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

Ribeiro

Serro-Azul

Lorena

et al. 2020

Front. Behav. Neurosci.

Self Cite

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“… 32 Recently, Pacífico with colleagues. 46 reported no difference in performance between controls and animals with SE at P9 in the Barnes maze test. Both the Barnes maze and MWM are tests of spatial memory, and other aspects of cognition are only exceptionally studied in animals experiencing SE during the first 2 weeks of life.…”

Section: Specific Demands Of Experiments With Neonatal and Infantile ...mentioning

confidence: 93%

“…Enhanced anxiety was reported in rats with SE at P9 tested as adults in the elevated plus-maze (EPM) and open field (OF) tests. 46,47 Alterations in anxiety/emotional behavior were observed in rats experiencing SE at P12 that were tested repeatedly as juveniles, adolescents, and adults 28,45 as well as in adult rats with SE at P15. 48 Aggressiveness is usually observed in this model in animals surviving SE at more mature stages, 49,50 but not in early life.…”

Section: Subclinical Srsmentioning

confidence: 99%

The outcome of early life status epilepticus—lessons from laboratory animals

2022

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Status epilepticus (SE) is the most common neurologic emergency in children. Both clinical and laboratory studies have demonstrated that SE in early life can cause brain damage and permanent behavioral abnormalities, trigger epileptogenesis, and interfere with normal brain development. In experimental rodent models, the consequences of seizures are dependent upon age, the model used, and seizure duration. In studies involving neonatal and infantile animals, the model used, experimental design, conditions during the experiment, and manipulation of animals can significantly affect the course of the experiments as well as the results obtained. Standardization of laboratory approaches, harmonization of scientific methodology, and improvement in data collection can improve the comparability of data among laboratories.

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Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats

Cited by 2 publications

References 14 publications

Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

Increased Endocannabinoid Signaling Reduces Social Motivation in Intact Rats and Does Not Affect Animals Submitted to Early-Life Seizures

The outcome of early life status epilepticus—lessons from laboratory animals

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