Dataset on hydrophobicity indices and differential scanning calorimetry thermograms for poly(HEMA)-based hydrogels

Bhat, Ankita; Smith, Blake; Dinu, Cerasela Zoica; Guiseppi‐Elie, Anthony

doi:10.1016/j.dib.2019.103891

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…About 5–10 mg of hydrated hydrogel was sealed into a hermetic pan (Tzero hermetic lid, 901684.901; Tzero pan, 901683.901) and equilibrated at −40 °C and heated to 30 °C at 10 °C/min under purging nitrogen (50 mL/min). Using TA analysis software, the endothermic peak was integrated to reveal the enthalpic contribution Δ H m of hydrogels at 0 °C . The enthalpy of freezable and bound water was assumed to be same as that of the bulk water (Δ H 0 = 334 J/g) .…”

Section: Methodsmentioning

confidence: 99%

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Toward Impedimetric Measurement of Acidosis with a pH-Responsive Hydrogel Sensor

2020

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A pH-responsive, poly(2-hydroxyethyl methacrylate) [poly(HEMA)]-based hydrogel has been fashioned into an impedimetric pH sensor for the continual measurement and monitoring of tissue acidosis that can arise due to hemorrhaging trauma. Four hydrogel systems molecularly engineered to influence water distribution and ionic abundance were studied: a cationogenic primary amine, N-(2-aminoethyl) methacrylate (AEMA), a tertiary amine moiety, N,N-(2-dimethylamino)ethyl methacrylate (DMAEMA), and a combined AEMA−DMAEMA formulation. Electrochemical impedance spectroscopy (EIS) of hydrogel discs held between platinized Type 304 stainless steel mesh electrodes in pH-adjusted 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid sodium salt (HEPES) buffer and equivalent circuit modeling indicated that the AEMA hydrogel had the highest sensitivity containing the relevant pathophysiological range (pH 7.0− 8.0). Thus, the AEMA formulation was studied at 0, 1, 3, 4.4, and 30 mol % AEMA. The 1 mol % AEMA was found to significantly (p < 0.05) discern nominal pH (7.35, 7.40, 7.45). The Taguchi Design of Experiments approach was employed and confirmed composition as a factor and 1 mol % AEMA to be the most robust. DMAEMA (0, 4.4, 14, 30 mol %) and AEMA−DMAEMA (0, 4.4, 14, 30 mol %) allowed the use of the one-factor Response Surface Methodology optimizer to confirm the AEMA 1 mol % system to be most robust, sensitive, and possessing optimal sensitivity in the pathophysiological pH sensing range (7.35−7.45) for hemorrhagic trauma. This composition was fashioned as a responsive membrane on a microlithographically fabricated interdigitated microsensor electrode and the sensitivity was determined using R(QR)(QR) analysis. Water distribution within the AEMA (0, 1, 4.4, 30 mol %), determined by gravimetric analysis and differential scanning calorimetry, revealed a strong anticorrelation between nonfreezable bound water and pH sensitivity (−0.82) and was in good agreement with the total hydration (−0.70). Nonfreezable bound water was found to be the most strongly correlated factor that governs the pH response of hydrogels.

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Section: Methodsmentioning

confidence: 99%

“…Using TA analysis software, the endothermic peak was integrated to reveal the enthalpic contribution ΔH m of hydrogels at 0 °C. 49 The enthalpy of freezable and bound water was assumed to be same as that of the bulk water (ΔH 0 = 334 J/g). 50 The freezable free water content and nonfreezable bound water content were calculated using the following equations…”

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confidence: 99%