Dataset on antitumor properties of silver nanoparticles from Gloriosa superba (L.) seed on Dalton Lymphoma Ascites (DLA) tumor: Facile and biocompatible approach

Abstract

The dataset depicted in this article related to our earlier article entitled “Phytofabrication and encapsulated of silver nanoparticles from Gloriosa Superba” (Saradha Devi et al., 2017) [1], which reports the characteristic features (UV Visible spectra, FTIR, SEM, TEM, DLS, Zeta potential and XRD analysis) of the Gloriosa superba biosynthesised silver nanoparticles (AgNPs). In this context, the present dataset was provided to identify the antioxidant, antitumor and apoptotic (in DLA cells) properties with the synthesized AgNPs. The result enlightens the AgNPs exhibits antitumor, apoptotic activity in DLA cells and antioxidant properties. The results of the in vivo experiments increased life span of liver cells in DLA induced tumour mice and not showed any histopathological variations between control and DLA induced mice animals. The HPTLC examination of the Gloriosa superba (L.) seed extract infers the presence of colchicines derivatives as a major alkaloid sources.

Exploring the therapeutic implications of nanoparticles for liquid tumors: A comprehensive review with special emphasis on green synthesis techniques in the context of Dalton’s lymphoma

“…Additionally, AgNPs protected with different groups like -CH2-, -NH2-, and -CO-of colchicines and colchicine derivatives of Gloriosa superba seeds extract were found to be non-cytotoxic to DL cells, while bare AgNPs were toxic, as reported by Devi et al (2017) (Devi et al, 2017). In the succeeding paper of the same group, these AgNPs were found to possess anti-tumor and antioxidant activities with no histopathological variation in tumor-bearing mice (Saradhadevi et al, 2017). Furthermore, a study based on silver nanoclusters (AgNc) was performed by Girigoswami et al (2018), where quantum yield was obtained on DL in different stages of AgNc synthesis to enhance the specificity of killing (Girigoswami et al, 2018).…”

Anticancer Secondary Metabolites: From Ethnopharmacology and Identification in Native Complexes to Biotechnological Studies in Species of Genus Astragalus L. and Gloriosa L.

“…However, the quantity of AG IV in AMHRCs is still low-0.02% dry weight (DW). The microbial biotransformation has been recognized to be superior to conventional chemical procedures for producing AG IV, owing to its high catalytic efficiency, inherent selectivity, low cost, and simple downstream processing [ 83 , 84 ]. There are many materials concerning fungus-mediated biocatalysis [ 83 , 85 , 86 , 87 ].…”

“…The microbial biotransformation has been recognized to be superior to conventional chemical procedures for producing AG IV, owing to its high catalytic efficiency, inherent selectivity, low cost, and simple downstream processing [ 83 , 84 ]. There are many materials concerning fungus-mediated biocatalysis [ 83 , 85 , 86 , 87 ]. An elicitation effect of immobilized Prunus canescens (IPC) has been reported for in vitro cultures of plants [ 101 ].…”

“…The fungi, especially the fungal endophytes, are a source of novel biocatalysts with numerous applications [ 103 ]. Currently, an ideal method in biotransformation procedures for producing biologically active substances represents the immobilization of microorganisms by Ca-alginate gel (CAG) [ 83 , 93 , 94 , 95 ]. Except through microorganisms’ biotransformation of exogenous substrates such as quercetin, kaempferol, and apigenin is achieved via suspension cultures of Astragalus vesicarius ssp.…”

Screening the elite chemotypes of Gloriosa superba L. in India for the production of anticancer colchicine: simultaneous microwave-assisted extraction and HPTLC studies

“…It's most popular and widespread use in traditional medicine is manifested against rheumatism and gout [12]. The tubers of the plant are traditionally used to treat chronic ulcers, colic, bruises and sprains, haemorrhoids, leprosy, cancer, and also as a labour pain inducer [13][14][15][16]. Pharmacological properties of the tuber indicate its use as an abortifacient, as well as anthelmintic, tonic and stomachic in smaller doses.…”