Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition

Abstract

We present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time (‘new’) or second time (‘old’) on a 1–6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extracellular waveforms, behavior, electrode locations determined from post-operative MRI scans, demographics, and the stimuli shown. As technical validation, we provide spike sorting quality metrics and assessment of tuning of cells to verify the presence of visually-and memory selective cells. We also provide analysis code that reproduces key scientific findings published previously on a smaller version of this dataset. Together, this large dataset will facilitate the investigation of the neural mechanism of declarative memory by providing a substantial number of hard to obtain human single-neuron recordings during a well characterized behavioral task.

Extent of Single-Neuron Activity Modulation by Hippocampal Interictal Discharges Predicts Declarative Memory Disruption in Humans

“…Activity was sorted to identify putative individual neurons using the semiautomatic template-matching algorithm OSort, which is available as open source (Rutishauser et al, 2006a). This method has been described in detail previously (Faraut et al, 2018). IEDs.…”

“…Memory task. The task used has been previously described (Rutishauser et al, 2015;Faraut et al, 2018). There are three versions of the task, which are all identical, except for the images shown.…”

“…For each patient, the microelectrode positions were localized from MRI scans performed after implantation of electrodes. These scans were registered to preoperative MRI scans using Freesurfer's MRI_robust_register as described previously (Faraut et al, 2018) (Fig. 1).…”

Human episodic memory retrieval is accompanied by a neural contiguity effect

“…in this paper is a subset of a publicly available dataset that has been published along with a paper that describes the methods in detail (Faraut et al, 2018b(Faraut et al, , 2018a. 1 Five sessions were rejected because memory accuracy was not sufficiently high (d < .5).…”

“…The recording methods and single-unit data analyses for this dataset have been described in detail before (Rutishauser et al, 2015;Faraut et al, 2018b). Briefly, the recordings analyzed here were obtained from depth electrodes implanted bilaterally within the hippocampus and amygdala (8 microwires each, 32 channels per patient in total).…”