Dataset for the reporting of carcinoma of the bladder—cystectomy, cystoprostatectomy and diverticulectomy specimens: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Compérat, Éva; Srigley, John R.; Brimo, Fadi; Delahunt, Brett; Koch, Michaël; López-Beltrán, Antonio; Reuter, Victor E.; Samaratunga, Hemamali; Shanks, Jonathan H; Tsuzuki, Toyonori; Kwast, Theodorus van der; Varma, Murali; Webster, Fleur; Grignon, David J.

doi:10.1007/s00428-019-02727-1

Cited by 12 publications

(19 citation statements)

References 78 publications

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“…1) especially with respect to the number and location of the Sections [9]. The International Collaboration on Cancer Reporting (ICCR) and the College of American Pathologists (CAP) have given recommendations which have already been discussed above [2]. In the author's experience, macroscopically evident lesions such as scars or red plaques (which can be CIS) are best visible and may be inked in the fresh cystectomy specimen, since their identification tends to become more difficult after fixation.…”

Section: Reporting Of Cystectomiesmentioning

confidence: 99%

“…According to WHO, CAP and ICCR guidelines [1][2][3]5], the presence of any urothelial component (including pTis) within a malignant lesion invokes the diagnosis of urothelial carcinoma. As notable exception, any quantity of neuroendocrine component yields the diagnosis of a neuroendocrine tumor and dictates its according management.…”

Section: Tumor Typementioning

confidence: 99%

“…Some studies especially tried to review this for micropapillary, sarcomatoid, lymphoepithelioma-like subtypes and carcinomas with divergent differentiation (glandular, squamous). Nevertheless, data are not robust, well-defined cut points are not yet available and most of these studies are limited in numbers and retrospective design [1,2,5,54].…”

Section: Subtypes (Formerly Variants) and Divergent Differentiationmentioning

confidence: 99%

“…One important milestone in genitourinary pathology was the 2005 modified Gleason score, but strict reporting standards have also been applied to other fields such as bladder cancer (BC). Following the groundwork laid by the WHO 2016, such standards are continually revised by the College of American Pathologists (CAP) and the International Collaboration on Cancer Reporting (ICCR), and are accessible to pathologists worldwide online [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Updated pathology reporting standards for bladder cancer: biopsies, transurethral resections and radical cystectomies

et al. 2021

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Aim Optimal management of bladder cancer requires an accurate, standardised and timely pathological diagnosis, and close communication between surgeons and pathologists. Here, we provide an update on pathology reporting standards of transurethral resections of the bladder and cystectomies. Methods We reviewed recent literature, focusing on developments between 2013 and 2021. Results Published reporting standards developed by pathology organizations have improved diagnosis and treatment. Tumor sub-staging and subtyping has gained increased attention. Lymph nodes continue to be an area of debate, and their staging has seen minor modifications. Several tasks, particularly regarding specimen preparation (“grossing”), are not yet standardized and offer opportunity for improvement. Molecular classification is rapidly evolving, but currently has only limited impact on management. Conclusion Pathological reporting of bladder cancer is continuously evolving and remains challenging in some areas. This review provides an overview of recent major developments, with a particular focus on published reporting standards.

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Section: Reporting Of Cystectomiesmentioning

confidence: 99%

Section: Tumor Typementioning

confidence: 99%

Section: Subtypes (Formerly Variants) and Divergent Differentiationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Updated pathology reporting standards for bladder cancer: biopsies, transurethral resections and radical cystectomies

et al. 2021

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“…Reporting tumor stage (pT), surgical margins (R0/1), and lymph node (LN) status (pN) is essential to guide clinical decisions [4]. Pathological societies have recommended reporting extranodal extension (ENE) and the greatest diameter of lymph node metastases [5]. Taking into account these and other details could result in more accurate staging and stratification.…”

Section: Introductionmentioning

confidence: 99%

Pathological reporting of cystectomy lymph nodes: a retrospective analysis of experience in Paris

et al. 2021

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Purpose Pathological evaluation of pelvic lymph node (LN) dissection (PLND) is important for management of cystectomy patients. However, challenges such as unclear interobserver variability of LN counting remain. Here, we assess interobserver variability of LN measures and their clinical utility, with a focus on variant histology. Methods We retrieved radical cystectomy cases with PLND between 2010 and 2016 and reevaluated pathological parameters; number of total and metastatic LN, LN density (LND), length of metastatic LN and metastases, extranodal extension (ENE). Results We report 96 patients: median age of 71a, 34 cases pN+, 36 cases with any extent of variant histology, median follow-up 10 months. Perivesical LN were only rarely identified, but frequently metastatic (4/9). Variant histology (34 cases) frequently exhibited LN metastasis (53% of pN+ cases). Interobserver variance was poor for total LN (kappa = 0.167), excellent for positive LN (0.85) and pN staging (0.96), and mediocre for LND (0.53). ROC analysis suggests that both LND and the sum of LN metastasis length may predict outcome (AUC 0.83 and 0.75, respectively). Conclusion Our study confirms the notion of LND as a prognostic measure, but cautions due to strong interobserver variance of LN counts. The sum length of LN metastases could be a measure that is independent of LN counts. We find that microscopically identified perivesical LN merit particular attention. In summary, our study highlights current challenges in pathological reporting of PLND, confirms previous observations and forms a basis for further studies.

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Re: J. Alfred Witjes, Harman Max Bruins, Richard Cathomas, et al. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines. Eur Urol 2021;79:82–104

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Montironi

2021

European Urology

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Dataset for the reporting of carcinoma of the bladder—cystectomy, cystoprostatectomy and diverticulectomy specimens: recommendations from the International Collaboration on Cancer Reporting (ICCR)

Cited by 12 publications

References 78 publications

Updated pathology reporting standards for bladder cancer: biopsies, transurethral resections and radical cystectomies

Updated pathology reporting standards for bladder cancer: biopsies, transurethral resections and radical cystectomies

Pathological reporting of cystectomy lymph nodes: a retrospective analysis of experience in Paris

Re: J. Alfred Witjes, Harman Max Bruins, Richard Cathomas, et al. European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2020 Guidelines. Eur Urol 2021;79:82–104

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