Datamining and functional environmental genomics reassess the phylogenetics and functional diversity of fungal monosaccharide transporters

Abstract

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Correlating sugar transporter expression and activities to identify transporters for an orphan sugar substrate

“…Surprisingly, 127 putative sugar transporters were found in the genome of A. oryzae (Lv et al 2020 ). On the other hand, the model yeast S. cerevisiae has only 25 sugar transporters in its genome, most of them (17) hexose transporters, two sensors, only three disaccharide transporters, and three polyol transporters (Barbi et al 2021 ; Donzella et al 2023 ). The basidiomycete Ustilago maydis , a pathogen of maize, also possesses a reduced number of sugar transporters (20), some of them capable of transporting pentoses and uronic acids, in contrast to S. cerevisiae (Wahl et al 2010 ).…”

“…3 , cluster 4). With respect to the monosaccharide mannose, Barbi et al ( 2021 ) observed a close association between glucose and mannose transport and found that out of the 49 published glucose transporters, only five could not transport mannose, including the l -arabinose transporter LAT-1 from N. crassa . This observation suggests that some of the glucose transporters from N. crassa may indeed also transport mannose.…”