Data Supplement from Glucose-6–phosphatase Is a Key Metabolic Regulator of Glioblastoma Invasion

Abstract

<p>Supplementary Figure S1, related to Experimental Procedures: Molecular characterization of primary BTICs. Supplementary Figure S2, related to Supplementary Figure 1: BTICs recover their proliferative and invasive capacities in vitro. Supplementary Figure S3, related to Supplementary Figure 3: BTICs express G6PC and its inhibition decreases cell migration, invasion and proliferation. Supplementary Figure S4, related to Supplementary Figure 3: G6PC knockdowns exhibit decreased cell invasion and migration. Supplementary Figure S5, related to Supplementary Figure 4: Pharmacological inhibition of G6PC induces an increase in the expression of the astrocytic marker GFAP in the recovery group. Supplementary Figure S6, related to Supplementary Figure 5: G6PC knockdown activates glycogen synthase (GYS1) and inhibits glycogen phosphorylase (PYGL). Supplementary Figure S7, related to Supplementary Figure 6: Invasion and proliferation capacity of BTICs in vivo.</p>