Data resource profile: Norwegian Databases for Drug Utilization and Pharmacoepidemiology

Sommerschild, Hilchen Thode; Berg, Christian; Jonasson, Christian; Husabø, Kari Jansdotter; Sharikabad, Mohammad Nouri

doi:10.5324/nje.v29i1-2.4040

Cited by 11 publications

(15 citation statements)

References 6 publications

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“…However, several limitations should be noted. Drug use in hospitals and nursing homes is not registered at an individual level in NorPD, 43 meaning that if many participants in HUNT3 received hypnotics only as patients in a clinical setting, our estimates may be too low. We had data from NorPD only 2 to 4 years before participation in HUNT3 (2006)(2007)(2008); thus, we were not able to take prescriptions of drugs used for sleep problems in earlier life into account.…”

Section: Discussionmentioning

confidence: 97%

“…Further details of the HUNT3 study are described elsewhere. 41 Data from all participants in the HUNT Study were linked to the Norwegian Prescription Database (NorPD) 43 through their unique Norwegian personal identification numbers to obtain information on purchases of prescribed hypnotic medication. All participants in the HUNT Study provided informed consent.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…The NorPD was established on January 1, 2004, at the Norwegian Institute of Public Health and contains data on all drugs approved by the Norwegian Medicines Agency dispensed in Norwegian pharmacies. 43,45 Purchases of prescribed drugs used for sleep problems were classified as hypnotics (N05) according to the Anatomical Therapeutic Chemical classification system (ATC). 46 These included benzodiazepine derivatives (N05CD); benzodiazepinerelated drugs, hereafter referred to as Z-drugs (N05CF); and melatonin receptor agonists, hereafter referred to as melatonin (N05CH).…”

Section: Hypnotic Medicationmentioning

confidence: 99%

See 2 more Smart Citations

Association Between Cardiorespiratory Fitness and Incident Purchase of Hypnotic Drugs in Adults: The HUNT Study

Ernstsen

Zotcheva²,

Sui³

et al. 2023

Mayo Clinic Proceedings

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Section: Discussionmentioning

confidence: 97%

Section: Study Design and Participantsmentioning

confidence: 99%

Section: Hypnotic Medicationmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Cardiorespiratory Fitness and Incident Purchase of Hypnotic Drugs in Adults: The HUNT Study

Ernstsen

Zotcheva²,

Sui³

et al. 2023

Mayo Clinic Proceedings

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“…Seeing as some analgesics are available over-the-counter (OTC), without a prescription, a possible explanation for this could be a decrease in use of OTC analgesics in favor of prescription analgesics. However, this seems unlikely as sales data indicate that the use of OTC analgesics has been fairly stable across the study period [ 44 ]. The increase in use of prescription paracetamol may to some degree result from an intentional shift from prescription of NSAIDs and analgesics with higher potential for misuse, to paracetamol [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Killing pain?: a population-based registry study of the use of prescription analgesics, anxiolytics, and hypnotics among all children, adolescents and young adults in Norway from 2004 to 2019

Stangeland

Handal

Aakvaag

et al. 2022

Eur Child Adolesc Psychiatry

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The ongoing opioid epidemic has been a global concern for years, increasingly due to its heavy toll on young people’s lives and prospects. Few studies have investigated trends in use of the wider range of drugs prescribed to alleviate pain, psychological distress and insomnia in children, adolescents and young adults. Our aim was to study dispensation as a proxy for use of prescription analgesics, anxiolytics and hypnotics across age groups (0–29 years) and sex over the last 15 years in a large, representative general population. The study used data from a nationwide prescription database, which included information on all drugs dispensed from any pharmacy in Norway from 2004 through 2019. Age-specific trends revealed that the prevalence of use among children and adolescents up to age 14 was consistently low, with the exception of a substantial increase in use of melatonin from age 5. From age 15–29, adolescents and young adults used more prescription drugs with increasing age at all time points, especially analgesics and drugs with higher potential for misuse. Time trends also revealed that children from age 5 were increasingly dispensed melatonin over time, while adolescents from age 15 were increasingly dispensed analgesics, including opioids, gabapentinoids and paracetamol. In contrast, use of benzodiazepines and z-hypnotics slightly declined in young adults over time. Although trends were similar for both sexes, females used more prescription drugs than their male peers overall. The upsurge in use of prescription analgesics, anxiolytics and hypnotics among young people is alarming.Trial registration The study is part of the overarching Killing Pain project. The rationale behind the Killing Pain research was pre-registered through ClinicalTrials.gov on April 7, 2020. Registration number NCT04336605; https://clinicaltrials.gov/ct2/show/record/NCT04336605.

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“…Two population-based registers with nationwide coverage were used: the Norwegian Primary Care Registry (KUHR) and the Norwegian Prescription Database (NorPD) [ 24 ]. The KUHR contains diagnoses codes (International Classification of Primary Care [ICPC]-2, International Classification of Diseases [ICD]-10) and claim codes from all primary care consultations since 2006, as well as patient demographics.…”

Section: Methodsmentioning

confidence: 99%

Changes in primary care management of atrial fibrillation patients following the shift from warfarin to non-vitamin K antagonist oral anticoagulants: a Norwegian population based study

Halvorsen

Smith²,

Söderdahl

et al. 2022

BMC Prim. Care

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Background To assess baseline characteristics, drug utilisation and healthcare use for oral anticoagulants (OACs) following the introduction of non-vitamin K antagonist oral anticoagulants among patients with atrial fibrillation in primary care in Norway. Methods In this retrospective longitudinal cohort study, 92,936 patients with atrial fibrillation were identified from the Norwegian Primary Care Registry between 2010 and 2018. Linking to the Norwegian Prescription Database, we identified 64,112 patients (69.0%) treated with OACs and 28,824 (31%) who were untreated. Participants were followed until 15 May 2019, death, or loss to follow-up, whichever came first. For each OAC, predictors of initiation were assessed by modelling the probability of initiating the OAC using logistic regression, and predictors of the first switch after index date were assessed using multivariable Cox proportional hazards models. The numbers of primary care visits per quarter by index OAC were plotted and analysed with negative binomial regression analyses offset for the log of days at risk. Results Patients treated with OACs were older, had more comorbidities, and higher CHA2DS2-VASc scores than untreated patients. However, the mean CHA2DS2-VASc in the non-OAC group was 1.58 for men and 3.13 for women, suggesting an indication for OAC therapy. The percentage of patients with atrial fibrillation initiating OACs increased from 59% in 2010 to 79% in 2018. Non-vitamin K antagonist oral anticoagulant use increased throughout the study period to 95% of new OAC-treated patients in 2018, and switches from warfarin to non-vitamin K antagonist oral anticoagulants were common. The persistence of OAC treatment was > 60% after four years, with greatest persistence for apixaban. Patients treated with non-vitamin K antagonist oral anticoagulants had fewer primary care visits compared with those treated with warfarin (incidence rate ratio: 0.73, 95% confidence interval 0.71 to 0.75). Conclusion In this Norwegian primary care study, we found that the shift from warfarin to non-vitamin K antagonist oral anticoagulants was successful with 95% use in patients initiating OACs in 2018, and associated with fewer general practitioner visits. Persistence with OACs was high, particularly for apixaban. However, many patients eligible for treatment with OACs remained untreated.

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Data resource profile: Norwegian Databases for Drug Utilization and Pharmacoepidemiology

Cited by 11 publications

References 6 publications

Association Between Cardiorespiratory Fitness and Incident Purchase of Hypnotic Drugs in Adults: The HUNT Study

Association Between Cardiorespiratory Fitness and Incident Purchase of Hypnotic Drugs in Adults: The HUNT Study

Killing pain?: a population-based registry study of the use of prescription analgesics, anxiolytics, and hypnotics among all children, adolescents and young adults in Norway from 2004 to 2019

Changes in primary care management of atrial fibrillation patients following the shift from warfarin to non-vitamin K antagonist oral anticoagulants: a Norwegian population based study

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