Data Reconciliation Using Neural Networks for the Determination of KLa

Patel, Nilesh; Thibault, Jules

doi:10.1007/978-3-642-01888-6_7

Cited by 1 publication

(1 citation statement)

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“…The volumetric gas‐liquid mass‐transfer coefficient, which is the product of liquid phase mass‐transfer coefficient and specific interfacial area, can be estimated by measuring dissolved oxygen concentrations over time or by using correlations available in the literature . The volumetric mass transfer may be treated as a black box and estimated using one of the data reconciliation techniques . The overall volumetric mass‐transfer coefficient can be expressed as a function of total specific power dissipated in the liquid .…”

Section: Modeling Of Bioreactor Hydrodynamicsmentioning

confidence: 99%

Review of the important challenges and opportunities related to modeling of mammalian cell bioreactors

2016

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Industrialization of mammalian cell culture has been achieved by integrating knowledge from several applying core concepts of chemical engineering, cellular and molecular biology, and biochemistry. Modeling has been applied to biological and physical processes to gain additional insights into such processes. This article covers modeling of the bioreactor and metabolic processes as it applies to bioprocess. Hydrodynamics of a bioreactor is briefly described while additional focus is given to gas‐liquid mass transfer. Biological modeling is presented in the order of increasing complexity. First steady state models are presented followed by dynamic models, cybernetic models, and finally bioreactor integrated models. The closing discussion summarizes challenges of implementation of model‐based approaches in the biopharmaceutical industry. © 2016 American Institute of Chemical Engineers AIChE J, 63: 398–408, 2017

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Section: Modeling Of Bioreactor Hydrodynamicsmentioning

confidence: 99%