Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications

Abstract

Characterization data of fluorescent nanoparticles made of cellulose acetate (CA-dots) are shown. The data in this article accompanies the research article “Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications” [1]. The measurements and calculation of brightness of individual CA-dots are presented. The description of conjugation procedure Pluronic F127-Folic Acid copolymer and folic acid is shown. Identification of composition of CA dots using Raman and absorbance spectroscopy is demonstrated. The methods for image analysis of efficiency of CA-dot targeting of epithelial tumors xenografted in zebrafish is presented.

The emergence of nanocarriers in the management of diseases and disorders

“…The Table 1 shows some of the reported researches and reviews on ultrabright nanocarriers. [5][6][7][8][9][10] Polymeric carriers Polymeric nanocarriers offer clinical potential. The polymeric nanocarrier is expected to have diagnostic and therapeutic uses.…”

“…Polymeric nanocarriers are useful for active or passive breast cancer targeting. [5] 2018 Cellulose acetate Ultrabright fluorescent nanoparticles For imaging tumors through systemic and topical applications 2 Melnychuk et al [6] 2018 Dyes in a polymer matrix Ultrabright fluorescent nanoparticles Amplified detection of nucleic acids 3 Goetz et al [7] 2016 Lanthanide Ultrabright nanoparticles Photosensitizing behaviour was used of targeting delivery 4 Shulov et al [8] 2015 Rhodamine Ultrabright nanoparticles For bioimaging and light-harvesting delivery 5 Sun et al [9] 2013 Polyethyleneimine Ultrabright/Multicolorful Fluorescence Combined imaging and therapy applied 6 Bok et al [10] 2012 Organosilicate Ultrabright suprananoparticles Fluorescence imaging for the theranostic application [11] 2019 Doxorubicin Polymeric nanoparticle Assessed of anticancer efficiency 2 Shelake et al [12] 2018 Fenofibrate Polymeric nanoparticle Bioavailability enhancement of the poorly soluble drugs 3…”

“…Since then, numerous different targeting strategies and carriers have been created based on novel facts on toxicity, tolerance, biocompatibility, and acceptability by living creatures. [5] Nanotheranostic techniques combine medication delivery and imaging enhancement in a single nanocapsules/system. Most nanoparticles can be coupled with polyethylene glycol (PEG) tails to promote colloidal stability and circulation with minimal blood protein adsorption in systemic circulation.…”

Imaging of Molecular Coating on Nanoparticle Surface Using AFM Ringing Mode

“…Furthermore, PEG coating on cellulose acetate particles can also be imaged in Ringing mode (though it is hard to estimate the resolution because of a rather smooth coating of cellulose acetate particles). Figure 1 shows a representative example of Ringing mode imaging of a nanoparticle made of mesoporous silica [4] and cellulose acetate [5,6]. Panel (a) shows the path of the AFM probe oscillating above the surface in a sub-resonance mode.…”

“…Figure 1 shows a representative example of Ringing mode imaging of a nanoparticle made of mesoporous silica [4] and cellulose acetate [5,6]. Panel (a) shows the path of the AFM probe oscillating above the surface in a sub-resonance mode.…”