Data on the effect of lead concomitant noise on oxidative stress in rats

Masruri, Batol; Ashtarinezhad, Azadeh; Yekzamani, Parvaneh

doi:10.1016/j.dib.2018.03.093

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…ROS may also indirectly induce the formation of DNA adducts by initiating autocatalytic lipid peroxidation, generating a large variety of potential genotoxic breakdown products, such as MDA [19]. Measurement of MDA levels in plasma or serum provide a convenient in vivo index of lipid peroxidation, and represent a non-invasive biomarker of oxidative stress [20].…”

Section: Discussionmentioning

confidence: 99%

Effects of inflammatory responses, apoptosis, and STAT3/NF-κB- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet

Shi

Dong

et al. 2019

Aging

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This study determined whether or not benign prostatic hyperplasia (BPH) induced by a high-fat diet (HFD) is involved in inflammatory responses, apoptosis, and the signal transducer and activator of transcription (STAT3)/nuclear factor-kappa B (NF-κB)- and nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated oxidative stress pathways. Forty rats were divided into four groups: control; HFD; testosterone; and HFD+testosterone. Hematoxylin and eosin (HE) staining was used to assess histologic changes. An enzyme-linked immunosorbent assay and Western blot analysis were used to detect levels of related proteins. Compared with the control group, the prostate levels of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), malondialdehyde (MDA), transforming growth factor-β1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) were significantly increased, while the levels of glutathione peroxidase (GSH-Px), glutathione reductase (GR), glutathione (GSH), and superoxide dismutase (SOD) were decreased. The TNF-κB, Bcl-2, and caspase-3 levels were increased, while the Bax level was markedly decreased. The cytoplasmic expression of STAT3 and NF-κB was increased, while the nuclear expression of Nrf2 was markedly decreased compared with the control group. In summary, our results demonstrated that a long-term HFD might cause changes in inflammatory responses, apoptosis, and oxidative stress, thus contributing to prostatic hyperplasia. The underlying mechanisms might be related to the STAT3/NF-κB- and Nrf2-mediated oxidative stress pathway.

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Section: Discussionmentioning

confidence: 99%

Effects of inflammatory responses, apoptosis, and STAT3/NF-κB- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet

Shi

Dong

et al. 2019

Aging

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“…Recently several investigations have exercised the influence of combined exposure to noise and chemical substances. The impact of noise and organic solvent on non-auditory system was reported by several investigators (10)(11)(12)(13). Exposure to noise and xylene induced biochemical alterations in rat heart muscle (10).…”

Section: Introductionmentioning

confidence: 92%

“…Heavy metals such as arsenic, mercury, cadmium and lead are present in many forms in the environment and are widely present in number of industrial sectors. It has been reported that combined exposure of noise and lead induced oxidative stress in rat serum (13). Additionally, Conetta et al found that the co-exposure of noise and cadmium produced histological damage in rat heart muscle (7).…”

Section: Introductionmentioning

confidence: 99%

Combined effect of cadmium and noise on rat’s kidney

2019

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Introduction: Recently, the consequence of chemical industries and noise on human health is the update subject for researchers. There are many reports published about nephrotoxicity of noise and cadmium alone. Objectives: The main aim of this study was to detect the combined consequence of noise and cadmium on renal function. Materials and Methods: Forty adult male rats were put into eight groups in random order (n=5). Groups 1 control, group 2 exposed to 90 dB (decibels) noise, groups 3- 5 received (intraperitoneal; ip) cadmium chloride (CdCl2) at doses of 1,2,3 mg/kg and group 6-8 pretreated with CdCl2 at doses of 1, 2, and 3 mg/kg 30 minutes before exposing to 90 dB noise. The exercise was repeated for seven consecutive days. Animals were killed 24 hours afterwards. Blood urea nitrogen (BUN) and creatinine (Cr) levels were analyzed. Kidney tissues were excised for measuring malondialdehyde (MDA) and glutathione (GSH) concentrations. Results: There was significant rise on the levels of BUN, Cr and MDA. Additionally, a decrease on the level of GSH in rats that were exposed to noise or cadmium alone or combined to noise and cadmium was detected. Significant elevation of BUN, Cr, MDA and depletion of GSH were also noted in cadmium-treated rats compared to those in the animals co-exposed to cadmium and noise. Conclusion: This study shows that exposed rats to cadmium and/or noise caused renal function impairment. Production of oxidative stress is responsible for cadmium or noise induced nephrotoxicity. However, co-exposure of cadmium and noise reduced nephrotoxicity of cadmium. The possible explanation for noises suppressing cadmium nephrotoxicity is that noise may enhance excretion and/or induced redistribution and depleted accumulation of cadmium in the kidney.

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“…The testis is very sensitive to oxidative stress due to its unsaturated fatty acids ( 17 ). Noise and lead appear to cause oxidative stress in various tissues, including the testes, by disturbing the balance of the prooxidant/antioxidant system ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Concurrent Lead and Noise Exposure Effects on Testicular Tissue of Rat: An Experimental Study

Masruri¹,

Alimohammadi²,

Abyaz³

et al. 2022

JFRH

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Objective: Environmental stressors such as physical and chemical factors can have a destructive testicular function. The present study aimed to determine the effect of concomitant exposure to lead and noise on testicular tissue in male rats. Materials and methods: Twenty male Wistar rats (250-300 g, 12-13wk) were divided into four groups (n=5/each): 1) Control group, 2) Lead group treated with 4 mg/kg lead acetate by gavage for 30 days, 3) Noise group exposed to 4 kHz octave band at 105 dBA for eight hrs./ day for 30 days, and 4) the exposed group to lead plus noise concurrently. The testes' weight was measured, and testes abnormalities were assessed after staining with Hematoxylin and Eosin. Results: The results showed that the weight of testes in experimental groups was significantly decreased compared with the control group (p<0.0001). Also indicated edema, degeneration and necrotic cell debris in the lumen, congestion and atrophy of seminiferous tubule in rat testes tissue due to sub-acute exposure to lead and noise. Conclusion: Exposure to 105 dB and lead can cause damage to the seminiferous tubules, intubation edema, and testicular weight loss compared to control. We also found that simultaneous exposure to noise and lead could have more detrimental effects on testicular histology and weight than others.

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Data on the effect of lead concomitant noise on oxidative stress in rats

Cited by 9 publications

References 4 publications

Effects of inflammatory responses, apoptosis, and STAT3/NF-κB- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet

Effects of inflammatory responses, apoptosis, and STAT3/NF-κB- and Nrf2-mediated oxidative stress on benign prostatic hyperplasia induced by a high-fat diet

Combined effect of cadmium and noise on rat’s kidney

Concurrent Lead and Noise Exposure Effects on Testicular Tissue of Rat: An Experimental Study

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