Data on spectral, optical and mechanical properties of 2-aminopyridine potassium dihydrogen orthophosphate (2APKDP) crystal

Sivavishnu, D.; Srineevasan, R.; Johnson, J.

doi:10.1016/j.cdc.2019.100264

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…2-Aminopyridine (CAS Reg. no., 504-29-0; structure, Figure ) is widely employed in a variety of applications of pharmaceuticals’ synthesis, especially for antihistamines, antiflammatories, and other drugs. , Brominated 2-aminopyridine attracted considerable attention for its applications as useful intermediates or building blocks for pharmaceuticals. − In particular, 2-aminopyridine also serves as an useful raw material for some liquid crystals. , Regardless of its wide applications, there has been little research into the thermodynamic properties of 2-aminopyridine in neat and mixed solvents. 2-Aminopyridine is generally obtained through the reduction of 2-nitropyridine or 2-halopyridine in various solvents such as ethanol, , methanol, acetonitrile, N -methyl-2-pyrrolidine (NMP), and so on.…”

Section: Introductionmentioning

confidence: 99%

“…no., 504-29-0; structure, Figure 1) is widely employed in a variety of applications of pharmaceuticals' synthesis, especially for antihistamines, antiflammatories, and other drugs. 5,6 Brominated 2-aminopyridine attracted considerable attention for its applications as useful intermediates or building blocks for pharmaceuticals. 7−9 In particular, 2-aminopyridine also serves as an useful raw material for some liquid crystals.…”

Section: ■ Introductionmentioning

confidence: 99%

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Investigation into Solubility and Solvent Effect of 2-Aminopyridine in Different Mono-Solvents Over Temperatures from 273.15 to 313.15 K

Liu

et al. 2022

J. Chem. Eng. Data

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The solubility data of 2-aminopyridine in 13 neat solvents were determined using the shake-flask method, including methanol, N,N-dimethylformamide (DMF), n-propanol, isopropanol, ethanol, n-butanol, N-methyl-2-pyrrolidine (NMP), isobutanol, n-hexane, cyclohexane, acetonitrile, amyl acetate, and n-propyl acetate. The mole fractions of 2-aminopyridine in equilibrium liquid phase rose with the increase in temperature and followed the decreasing order in different solvents: NMP > DMF > methanol > ethanol > n-propanol > n-butanol > n-propyl acetate > amyl acetate > isopropanol > isobutanol > acetonitrile > n-hexane > cyclohexane. The λh equation, NRTL model, modified Apelblat equation, and Wilson model were used to fit them. The greatest root-mean-square deviation value and relative average deviation value obtained were 160.4 × 10–4 and 4.46 × 10–2, respectively. For a given solvent, the modified Apelblat equation produced lower relative average deviation values than the other equations. The mixing characteristics, infinitesimal concentration activity coefficient, and reduced excess enthalpy were also calculated. Furthermore, the degree and type of interactions of solute–solvent and solvent–solvent were identified utilizing the relationship analysis of Kamlet and Taft linear solvation energy of solvent effect.

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