Data on peptidyl platform-based anticancer drug synthesis and triton-x-based micellar clusters (MCs) self-assembly peculiarities for enhanced solubilization, encapsulation of hydrophobic compounds and their interaction with HeLa cells

Abstract

The data presented here refer to a research article entitled “Self-Assembled Micellar Clusters Based on Triton-X-family Surfactants for Enhanced Solubilization, Encapsulation, Proteins Permeability Control, and Anticancer Drug Delivery” Solomonov et al., 2019. The present article provides the General Procedure for clusterization of Triton-X-based micelles and the effect of (i) metal ion, surfactant, and chelator concentration on the developed clusters formation, (ii) surfactant-chelator relation change, (iii) metal ion-micelles concertation ratio variation, (iv) metal ion replacement, (v) solvent replacement, (vi) kinetics of clusters formation, (vii) hydrophobic fluorescent dye (Coumarin 6) solubilization in aqueous MCs media, (viii) novel anticancer peptidyl drug synthesis and characterization and (ix) the viability of HeLa cells with and without the presence of drug-free Triton-X-based family MCs. These data provide additional insights useful for understanding all aspects of the micellar clusters formation, optimization, and control.

Dataset for the Synthesis of Boron-Dipyrrin Dyes, their fluorescent properties, their interaction with proteins, Triton-X-based surfactants, and micellar clusterization approaches to validation based on fluorescent dyes

“…The formed features, stability, kinetics, and the optimal formation conditions (component concentrations and their ratios; metal ions and solvent replacement) of the TX-100/TX-114-based MCCs, as well as the effect of external factors (e.g., pH, temperature, and the addition of competing chelators) on the clusterization process, system stability, and the encapsulation abilities using Coumarin 6 have been studied and reported previously ( Fig. 4 , C, D) [9 , 10] . Despite their structural similarity, TX-114 has a lower cloud point temperature, compared with TX-100; therefore, the effect of a cloud point change on the micellar clusterization process was studied to investigate BODIPY encapsulation and the fluorescent characteristics.…”

Self‐Assembly in Protein‐Based Bionanomaterials

“…[3] Indeed, self-assembly is a convenient strategy and it is characterized by constructing various highly ordered nano-or micro-architectures. [4][5][6] The formed structures could be easily used as building blocks for designing biomaterials with diverse functionalities. [7,8] Self-assembly has been widely used in chemistry, biology, and materials science as a "bottom-up" approach for developing highly ordered structures at the nanoto micrometer scale with controllable levels of complexity.…”

“…Indeed, self‐assembly is a convenient strategy and it is characterized by constructing various highly ordered nano‐ or micro‐architectures [4–6] . The formed structures could be easily used as building blocks for designing biomaterials with diverse functionalities [7,8] .…”