Data on histological characteristics, survival patterns and determinants of mortality among colorectal, esophageal and prostate cancer patients in Ethiopia

Abstract

This article describes data collected retrospectively on a cohort of esophageal, colorectal and prostate cancer patients registered in the patient log book of Tikur Anbessa Specialized Hospital, Ethiopia, from January 1, 2012 to December 31, 2017. The key variables studied include histological characteristics of each type of cancer, clinical and TNM stages, baseline laboratory results (Carcinoembryonic antigen (CEA) for colorectal cancer, Prostate-Specific Antigen (PSA) for prostate cancer, hemoglobin level, etc.), clinical characteristics including sign and symptoms, family history of cancer, diagnostic and treatment modalities a patient received for each type of cancer. The event status (death) was also collected using death certificates (whenever available) and supplemented by telephone interviews with the patient or attendant. Furthermore, lifestyle characteristics of patients including tobacco use, alcohol consumption, khat (‘ Catha edulis ’) chewing, etc. and socioeconomic characteristics including age, sex, region of residence, marital status, and educational level were also collected. The aim that led to conduct the study that generated these data was to describe clinical presentation, histological characteristics, survival pattern, and to identify determinants of mortality among cancer patients in Ethiopia. Thus, independent survival analyzes were performed using Kaplan-Meier estimates and life table analysis. Furthermore, Cox's proportional hazards regression was developed to investigate the survival pattern and determinants of cancer specific mortality among colorectal, esophageal and prostate cancer patients.

Clinical presentation, treatment patterns, and outcomes of colorectal cancer patients at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia: A prospective cohort study

“…This is similar to a retrospective study in Ghana, where the 1‐year survival rate was 64% 29 . Comparatively to other regions, SSA has a low rate of CRC survival, where a meta‐analysis found the 1‐year survival is 74%, and even lower in lower income countries 32 . Our finding is far lower than many other studies performed in different parts of the world, such as a study from Brazil, where the 5‐year OS was 63.5% and 60.6% for colonic and rectal malignancies, respectively, 33 and a Chinese study where the 3‐ and 5‐year OS was 74% and 68%, respectively 26 .…”

“…29 Comparatively to other regions, SSA has a low rate of CRC survival, where a meta-analysis found the 1-year survival is 74%, and even lower in lower income countries. 32 Our finding is far lower than many other studies performed in different parts of the world, such as a study from Brazil, where the 5-year OS was 63.5% and 60.6% for colonic and rectal malignancies, respectively, 33 and a Chinese study where the 3-and 5-year OS was 74% and 68%, respectively. 26 In a study in Vietnam, the 1, 3, and 5 OS survival showed 84.7%, 56%, and 45%, respectively, 34 which are greater than 1-year survival of our patients and this demonstrates the need of addressing the situation, which necessitates the involvement of all stakeholders.…”

Clinical feature, treatment pattern and survival of Esophageal cancer at Tikur Anbessa Specialized Hospital, Ethiopia: a prospective cohort study

“…The final model for patients with esophageal cancer was established for 170 patients. The final model was significant (X 2 (10) = 37.331, P=0.000). Performance status at presentation, treatment with chemotherapy, local recurrence, and brain metastases were the variables that explained the model.…”

“…A study in the United States on the survival of esophageal cancer patients revealed a 10-year survival rate of 14% (9). In Ethiopia, however, the survival of patients with esophageal cancer has not shown any significant improvement over the decades (10). This disease has caused the death of patients in different hospitals, with wide geographical coverage across the nation, which reflects it as a significant health problem.…”

Health-related quality of life assessment among patients with oesophageal cancer at Tikur Anbessa Specialised Tertiary Hospital in Ethiopia: a cross sectional study

“…In Ethiopia, patients with oesophageal cancer often present at an advanced stage owing to a variety of factors, such as low health-seeking behaviours, limited access to hospitals and trained personnel, lack of early screening or diagnosis facilities, and low literacy levels [ 8 ]. All of these factors significantly impact the quality of health of patients with oesophageal cancer.…”