Data on antiplatelet aggregation, anticoagulation and antioxidant activities of Canna edulis Ker rhizome and its secondary metabolites

Abstract

Canna edulis Ker rhizome has been used in Traditional Vietnamese Medicine to prevent and treat heart diseases without thorough scientific evidence. The data presented in this article characterize the antiplatelet aggregation, anticoagulant and antioxidant activity of C. edulis rhizome extracts and the bio-guided isolation of bioactive compounds from the active fraction. The data on tested bioactivities of isolated compounds were also provided. The inhibitory effect on adenosine diphosphate- and collagen-induced human platelet aggregation was evaluated through three parameters: percentage inhibition of platelet aggregation, aggregation velocity and area under the platelet aggregation curve. Prothrombin time, activated partial thromboplastine time and thrombine time were measured to examine the anticoagulant activity. The free radical scavenging ability was assessed with DPPH and ABTS assays. The structures of compounds were elucidated by NMR and MS spectroscopic methods. The data showed that the ethyl acetate fraction showed the most potent antiplatelet aggregation, anticoagulant and antioxidant activity. Seven known compounds: 5-hydroxy-6-methyl-2 H -pyran-2-one (1) , epimedokoreanone A (2) , nepetoidin B (3) , ferulic acid (4) , caffeic acid (5) , hydroxytyrosol (6) , and 1H-indole-3-carboxaldehyde (7) were isolated from this active fraction. Moreover, this article provided experimental data on antiplatelet effect of epimedokoreanone A (2) and nepetoidine B (3) , anticoagulant and antioxidant activity of epimedokoreanone A (2) and also antiplatelet and antioxidant activity of 5-hydroxy-6-methyl-2 H -pyran-2-one (1) .

Structural analysis of type 3 resistant starch from Canna edulis during in vitro simulated digestion and its post-digested residue impact on human gut microbiota

“…Canna edulis ( C. edulis ) is a perennial herb with high medicinal value. In traditional medicine, C. edulis is used to prevent and treat heart disease ( 7 ). C. edulis tubers contain several flavonoids with excellent gastroprotective effects, reducing the ulcer index and preventing pathology in alcoholic gastritis ( 8 ).…”

Systematic Characterization of the Chemical Components of Canna edulis Ker-Gawl Based on UHPLC Q-Exactive Orbitrap MS Technology

“…Modern pharmacological studies have found that Canna edulis Ker -Gawl protects the liver and gallbladder, treats acute jaundice hepatitis, has a gastroprotective efect [15], lowers blood pressure, lowers blood glucose, lowers blood lipids, prevents colon cancer [16], and cardiovascular disease [17,18] and has antioxidant activities [19,20]. Previous studies from our group [21][22][23][24][25] found that the resistant starch from the rhizome of Canna edulis Ker (Ce-RS3) after 11 weeks of Ce-RS3 intervention showed antidiabetic efects similar to metformin, signifcantly reduced blood glucose, reduced insulin resistance, increased glucose tolerance, and reduced pathological damage.…”