Data on antiplasmodial and stage-specific inhibitory effects of Aromatic (Ar)-Turmerone against Plasmodium falciparum 3D7

Ali, Amatul Hamizah; Agustar, Hani Kartini; Hassan, Nurul Izzaty; Latip, Jalifah; Embi, Noor; Sidek, Hasidah Mohd

doi:10.1016/j.dib.2020.106592

Cited by 5 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The antimalarial threshold activities are determined as follows, EC 50 < 1 μM as potential activity, 2–20 μM as active/good activity, 21–100 μM as moderate activity, 101–200 as weak activity, and EC 50 > 201 as inactive. 34–36 The EC 50 values for the reference antimalarial drug, chloroquine diphosphate (CQ) 0.04 μM for P. knowlesi A1H1 and 0.0018 μM for P. falciparum 3D7 in line with its usage as the frontline drug for treating malarial infection. The EC 50 value of 2a against the A1H1 strain was about 66-fold higher than CQ, while the EC 50 value of 2a against 3D7 was about 48-fold higher than CQ.…”

Section: Resultsmentioning

confidence: 99%

Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis

Syahri,

Hilma,

Ali

et al. 2023

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis

Syahri,

Hilma,

Ali

et al. 2023

RSC Adv.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The sesquiterpenes such as caryophyllene, trans-α-bergamotene, curcumene, β-sesquiphellandrene, and curcumol have anti-inflammatory effects. The main component ar-turmerone has anti-inflammatory, anti-malarial, anti-cancer, and neuroprotective effects [ 21 , 22 , 23 ]. The literature has shown that ar-turmerone can protect the dopaminergic neurons in the midbrain, as evidenced by slice cultures of their activities [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…The literature has shown that ar-turmerone can protect the dopaminergic neurons in the midbrain, as evidenced by slice cultures of their activities [ 22 ]. Ar-turmerone has inhibitory effects against plasmodium falciparum 3D7 [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…The sesquiterpenes such as caryophyllene, trans-α-bergamotene, curcumene, β-sesquiphellandrene, and curcumol have anti-inflammatory effects. The main component ar-turmerone has anti-inflammatory, anti-malarial, anti-cancer, and neuroprotective effects [21][22][23]. The According to the MS data, the compounds of seven characteristic peaks detected by GC-SAW were identified.…”

Section: Turmeric Sample Gc-ms Testmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Determination and Quality Control of Pharmacological Volatiles of Turmeric (Curcuma longa L.) by Fast Gas Chromatography–Surface Acoustic Wave Sensor

Wang

Shen

et al. 2021

Molecules

View full text Add to dashboard Cite

Introduction: A novel analytical method using fast gas chromatography combined with surface acoustic wave sensor (GC-SAW) was developed for rapid determination of the pharmacological volatiles of turmeric (Curcuma longa L.). Methods: The volatile compounds in 20 turmeric samples, collected from different parts and different origins, were assessed by the fast GC-SAW. In addition, gas chromatography–mass spectrometry (GC-MS) was employed to confirm the chemical composition of the main volatiles. The digital fingerprint of turmeric was established and analysed by principal component analysis and cluster analysis. Results: Curcumene (9.1%), β-sesquiphellandrene (5.1%) and ar-turmerone (69.63%) were confirmed as the main pharmacological volatiles of turmeric. The content of ar-turmerone in lateral rhizome turmeric was significantly higher than that of top rhizome and ungrouped turmeric. The contents of curcumene and β-sesquiphellandrene in top rhizome turmeric were higher than those in lateral and ungrouped turmeric. The 20 turmeric samples were divided into four categories, which reflected the quality characteristics of the turmeric from different parts and origins. Conclusion: The GC-SAW method can rapidly and accurately detect pharmacologically volatiles of turmeric, and it can be used in the quality control of turmeric.

show abstract

“…The anti-malarial reference drug CQ used ranged from 0.0001 to 10 µM. The assay was based on the lactate dehydrogenase enzymatic reaction (pLDH) [ 62 , 63 ]. After 48 h incubation of P. falciparum cultures with test compounds, Malstat and NBT/PES reagents were added to allow colour changes.…”

Section: Methodsmentioning

confidence: 99%

Dual Anti-Malarial and GSK3β-Mediated Cytokine-Modulating Activities of Quercetin Are Requisite of Its Potential as a Plant-Derived Therapeutic in Malaria

et al. 2021

Self Cite

View full text Add to dashboard Cite

Although death in malaria is attributed to cerebrovascular blockage and anaemia, overwhelming cytokine production can contribute to the severity of the disease. Therefore, mitigation of dysregulated inflammatory signalling may provide further benefit for malaria treatment. Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is known to inhibit glycogen synthase kinase-3β (GSK3β), a potent regulator of both pro- and anti-inflammatory effects. Quercetin is therefore a potential therapeutic to modulate the imbalanced cytokine production during malarial infection. Anti-malarial effects of quercetin were evaluated in murine models of severe and cerebral malaria using Plasmodium berghei NK65 and ANKA strains, respectively. Western blotting and analysis of cytokines were carried out to determine the GSK3β-mediated cytokine-modulating effects of quercetin in infected animals. Quercetin (25 mg/kg BW) treatment in P. berghei NK65-infected animals resulted in 60.7 ± 2.4% suppression of parasitaemia and significantly decreased serum levels of TNF-α and IFN-γ, whilst levels of IL-10 and IL-4 were elevated significantly. Western analysis revealed that pGSK3β (Ser9) increased 2.7-fold in the liver of quercetin-treated NK65-infected animals. Treatment of P. berghei ANKA-infected mice with quercetin (15 mg/kg BW) increased (2.3-fold) pGSK3β (Ser9) in the brains of infected animals. Quercetin is a potential plant-derived therapeutic for malaria on the basis that it can elicit anti-malarial and GSK3β-mediated cytokine-modulating effects.

show abstract

Data on antiplasmodial and stage-specific inhibitory effects of Aromatic (Ar)-Turmerone against Plasmodium falciparum 3D7

Cited by 5 publications

References 5 publications

Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis

Chalcone Mannich base derivatives: synthesis, antimalarial activities against Plasmodium knowlesi, and molecular docking analysis

Rapid Determination and Quality Control of Pharmacological Volatiles of Turmeric (Curcuma longa L.) by Fast Gas Chromatography–Surface Acoustic Wave Sensor

Dual Anti-Malarial and GSK3β-Mediated Cytokine-Modulating Activities of Quercetin Are Requisite of Its Potential as a Plant-Derived Therapeutic in Malaria

Contact Info

Product

Resources

About