Data Mining and Comparative Analysis of Human Skin Microbiome from EBI Metagenomics Database

Nuhamunada, Matin; Pratama, Gregorius Altius; Wikanthi, Setianing; Anam, Mohamad Khoirul; Rizki, Rabudin; Wijayanti, Nastiti

doi:10.1109/biomic.2018.8610588

Cited by 1 publication

(2 citation statements)

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“…It was reported that multilocus sequence typing (MLST) based on housekeeping genes, of M. ulcerans isolates resulted in six contrasting genotypes from wideranging biogeographical regions of the world (Narh et al 2014). Comparative DNA analysis between samples from water, soil, biofilms, and clinical samples, from Buruli ulcer patients in South Togo revealed similar M. ulcerans genetic profile (Maman et al 2018).…”

Section: Sur and Palmentioning

confidence: 99%

“…The samples from Buruli ulcer lesions exhibited higher proportion of unassociated bacteria like Bacteroides and obligate anaerobes, in contrast to non Buruli ulcer lesions (Van Leuvenhaege et al 2017). Since, skin microbiome is influenced by geography, genetics, climatic condition etc., its comparative study on a large scale should be used for estimating diversity in different populations (Nuhamunada et al 2018). This work on Buruli ulcer lesions from Benin underlined that, additional microbiome-based analysis should be accompanied with standard microbiological studies.…”

Section: Sur and Palmentioning

confidence: 99%

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Comprehensive review of Mycobacterium ulcerans and Buruli ulcer from a bioinformatics perspective – what have we learnt?

Sur¹,

Pal²

2022

Acta Biol Szeged

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Mycobacterium ulcerans is a non-tuberculous mycobacterium responsible for causing Buruli ulcer. This is a neglected tropical disease characterized by ulceration, necrotization and scarring of the soft tissues in human limbs. Pathogenesis of M. ulcerans is mediated by a cytotoxic and immunosuppressive compound called mycolactone. This steadily evolving mycobacteria has adapted itself with the aquatic insect ecosystem. Human communities in wetland ecosystems are prone to Buruli ulcer and several endemic regions have been identified. So far, there is no vaccine and surgery or prolonged treatment with antibiotic cocktail has been mandated to overcome resistance patterns. Application of bioinformatics tools in M. ulcerans and Buruli ulcer research during the post genomic era, has provided immense opportunities. In this review, we summarize the outcome of genome studies, comparative genomics, population genomics, genetic diversity analysis, phylogenetic studies and proteomics research pertaining to this disease. We also highlight the implications of in silico vaccine design and computational studies on natural products. Resultant findings are conducive for interpreting genome architecture, pathogenomic evolution and intraspecific divergence due to phylogeographic and virulence factors of M. ulcerans. Moreover, the outcome of population genomics studies in disease management, coupled with the efforts in discovering vaccine candidates and novel lead compounds, will enrich our understanding of Buruli ulcer.

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Section: Sur and Palmentioning

confidence: 99%

Section: Sur and Palmentioning

confidence: 99%