Abstract:<div>Abstract<p>Aberrant Wnt signaling drives a number of cancers through regulation of diverse downstream pathways. Wnt/β-catenin signaling achieves this in part by increasing the expression of proto-oncogenes such as <i>MYC</i> and cyclins. However, global assessment of the Wnt-regulated transcriptome <i>in vivo</i> in genetically distinct cancers demonstrates that Wnt signaling suppresses the expression of as many genes as it activates. In this study, we examined the set … Show more
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