Abstract:<div>AbstractPurpose:<p>Clinical trials of venetoclax reported negligible rates of clinical tumor lysis syndrome (TLS) in patients with chronic lymphocytic leukemia (CLL) when using an extended dose escalation schedule. We aimed to understand TLS prophylaxis, rates of select adverse events (AE), and impact of dosing modifications in routine clinical practice.</p>Experimental Design:<p>This retrospective cohort study included 297 CLL venetoclax-treated patients outside of clinical trials… Show more
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