Abstract:<div>AbstractPurpose:<p>The heavy chain of the CD98 protein (CD98hc) is encoded by the <i>SLC3A2</i> gene. Together with the light subunit LAT1, CD98hc constitutes a heterodimeric transmembrane amino acid transporter. High <i>SLC3A2</i> mRNA expression levels are associated with poor prognosis in patients with head and neck squamous cell carcinoma (HNSCC) treated with radiochemotherapy. Little is known regarding the CD98hc protein–mediated molecular mechanisms of tumor radio… Show more
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