Abstract:<div>Abstract<p>ATP-competitive fibroblast growth factor receptor (FGFR) kinase inhibitors, including BGJ398 and Debio 1347, show antitumor activity in patients with intrahepatic cholangiocarcinoma (ICC) harboring activating <i>FGFR2</i> gene fusions. Unfortunately, acquired resistance develops and is often associated with the emergence of secondary <i>FGFR2</i> kinase domain mutations. Here, we report that the irreversible pan-FGFR inhibitor TAS-120 demonstrated efficacy in… Show more
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