Data from Targeting the PI3K/mTOR Pathway Augments CHK1 Inhibitor –Induced Replication Stress and Antitumor Activity in High-Grade Serous Ovarian Cancer
Abstract:<div>Abstract<p>High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecologic malignancy in industrialized countries and has limited treatment options. Targeting ataxia-telangiectasia and Rad3-related/cell-cycle checkpoint kinase 1 (CHK1)-mediated S-phase and G<sub>2</sub>–M-phase cell-cycle checkpoints has been a promising therapeutic strategy in HGSOC. To improve the efficacy of CHK1 inhibitor (CHK1i), we conducted a high-throughput drug combination screening in HGSOC cel… Show more
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