Abstract:<div>Abstract<p><b>Purpose:</b> The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study, we investigated the potential of targeting the catalytic class I<sub>A</sub> PI3K isoforms in small cell lung cancer (SCLC), which is the most aggressive of all lung cancer types.</p><p><b>Experimental Design:</b> The expres… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.