Abstract:<div>Abstract<p>TAp63 is a p53 family member and potent tumor and metastasis suppressor. Here, we show that <i>TAp63<sup>−/−</sup></i> mice exhibit an increased susceptibility to ultraviolet radiation–induced cutaneous squamous cell carcinoma (cuSCC). A human-to-mouse comparison of cuSCC tumors identified miR-30c-2* and miR-497 as underexpressed in TAp63-deficient cuSCC. Reintroduction of these miRNAs significantly inhibited the growth of cuSCC cell lines and tumors. Proteom… Show more
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