Abstract:<div>Purpose:<p>Drug repurposing offers the opportunity for chemotherapy to be used to reestablish sensitivity to immune checkpoint blockade (ICB) therapy. Here we investigated the clinical and translational aspects of an early phase II study of azacitidine and carboplatin priming for anti-PDL1 immunotherapy (avelumab) in patients with advanced ICB-resistant melanoma.</p>Experimental Design:<p>A total of 20 participants with ICB-resistant metastatic melanoma received 2 × 4-week cycles o… Show more
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