Abstract:<div>Abstract<p>In human cutaneous malignant melanoma, a predominance of activated mutations in the N-<i>ras</i> gene has been documented. To obtain a mouse model most closely mimicking the human disease, a transgenic mouse line was generated by targeting expression of dominant-active human N-<i>ras</i> (N-Ras<sup>Q61K</sup>) to the melanocyte lineage by tyrosinase regulatory sequences (Tyr::N-Ras<sup>Q61K</sup>). Transgenic mice show hyperpigmented s… Show more
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