Abstract:<div>Abstract<p>Metastatic melanoma represents a complex and heterogeneous disease for which there are no therapies to improve patient survival. Recent expression profiling of melanoma cell lines identified two transcription signatures, respectively, corresponding with proliferative and invasive cellular phenotypes. A model derived from these findings predicts that <i>in vivo</i> melanoma cells may switch between these states. Here, DNA microarray–characterized cell lines were subjected… Show more
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