Data from <i>IKZF1</i> Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities
Abstract:<div>Abstract<p>SNPs in <i>IKZF1</i> are associated with inherited susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Besides, somatic copy number abnormalities (CNA) in genes related to lymphopoiesis (e.g., <i>IKZF1, CDKN2A/B, BTG1</i>) impact patient's outcome. Therefore, this study aimed to investigate an association between germline susceptibility and CNAs in BCP-ALL. The <i>IKZF1</i> SNPs (rs11978267 and rs4132601) were genotyped in 2… Show more
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