Data from Large-Scale <i>In Vitro</i> and <i>In Vivo</i> CRISPR-Cas9 Knockout Screens Identify a 16-Gene Fitness Score for Improved Risk Assessment in Acute Myeloid Leukemia
Abstract:<div>AbstractPurpose:<p>The molecular complexity of acute myeloid leukemia (AML) presents a considerable challenge to implementation of clinical genetic testing for accurate risk stratification. Identification of better biomarkers therefore remains a high priority to enable improving established stratification and guiding risk-adapted therapy decisions.</p>Experimental Design:<p>We systematically integrated and analyzed the genome-wide CRISPR-Cas9 data from more than 1,000 <i>in v… Show more
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