Abstract:<div>Abstract<p><b>Purpose:</b> Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death, and iron overload is a significant risk factor in the development of HCC. In this study, we investigated the potential application of depriving iron by a novel iron chelator, thiosemicarbazone-24 (TSC24), in HCC treatment.</p><p><b>Experimental Design:</b> Two HCC cell lines and HFE knockout (HFE<sup>−/−</sup>) mice were used to deter… Show more
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