Abstract:<div>Abstract<p><b>Purpose:</b> Polyamines are important regulators of cell growth and death. The polyamine modulated factor-1 (PMF-1) is involved in polyamine homeostasis. After identifying an enriched CpG island encompassing the PMF1 promoter, we aimed at evaluating the clinical relevance of PMF1 methylation in bladder cancer.</p><p><b>Experimental Design:</b> The epigenetic silencing of PMF1 by hypermethylation was tested in bladder cancer cells (<i>n<… Show more
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