Abstract:<div>Abstract<p>Mutations in the <i>KRAS</i> oncogene are found in more than 90% of patients with pancreatic ductal adenocarcinoma (PDAC), with Gly-to-Asp mutations (<i>KRAS</i><sup>G12D</sup>) being the most common. Here, we tested the efficacy of a small-molecule KRAS<sup>G12D</sup> inhibitor, MRTX1133, in implantable and autochthonous PDAC models with an intact immune system. <i>In vitro</i> studies validated the specificity and potency… Show more
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