Abstract:<div>Abstract<p><b>Purpose:</b> The cancer stem cell hypothesis predicts that standard prostate cancer monotherapy eliminates bulk tumor cells but not a tumor-initiating cell population, eventually leading to relapse. Many studies have sought to determine the underlying differences between bulk tumor and cancer stem cells.</p><p><b>Experimental Design:</b> Our previous data suggest that the PTEN/PI3K/AKT pathway is critical for the <i>in vitro</i>main… Show more
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