Abstract:<div>AbstractPurpose:<p>Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the contribution of L-2-HG to renal carcinogenesis and insight into the biochemistry and targets of this small molecule remains to be elucidated.</p>Experimental Design:<p>Genetic and pharmacologic approaches to modulate L-2-HG levels were assessed for effects on <i>in vitro</i> and <i>in vivo&l… Show more
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