Data from Anti-EFNA4 Calicheamicin Conjugates Effectively Target Triple-Negative Breast and Ovarian Tumor-Initiating Cells to Result in Sustained Tumor Regressions
Abstract:<div>Abstract<p><b>Purpose:</b> Triple-negative breast cancer (TNBC) and ovarian cancer each comprise heterogeneous tumors, for which current therapies have little clinical benefit. Novel therapies that target and eradicate tumor-initiating cells (TIC) are needed to significantly improve survival.</p><p><b>Experimental Design:</b> A panel of well-annotated patient-derived xenografts (PDX) was established, and surface markers that enriched for TIC in specific tumo… Show more
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