Abstract:<div>Abstract<p>The HER2-targeted therapy trastuzumab is widely used for the treatment of patients with metastatic breast tumors overexpressing HER2. However, an objective response is observed in only 12% to 24% of patients treated with trastuzumab as a single agent and initial responders regress in <6 months (<a href="#bib1" target="_blank">1</a>–<a href="#bib3" target="_blank">3</a>). The reason for the clinical failure of trastuzumab in this setting remains unclear. He… Show more
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