Abstract:<div>Abstract<p>Activation of FGFR signaling through mutations, amplifications, or fusions involving <i>FGFR1, 2, 3</i>, or <i>4</i> is seen in multiple tumors, including lung, bladder, and cholangiocarcinoma. Currently, several clinical trials are evaluating the role of novel FGFR inhibitors in solid tumors. As we move forward with FGFR inhibitors clinically, we anticipate the emergence of resistance with treatment. Consequently, we sought to study the mechanism(s) of acqui… Show more
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