Data from Aflibercept Exerts Antivascular Effects and Enhances Levels of Anthracycline Chemotherapy <i>In vivo</i> in Human Acute Myeloid Leukemia Models
Abstract:<div>Abstract<p>We examined whether potent vascular endothelial growth factor (VEGF) blockade mediated by aflibercept, a decoy VEGF receptor (VEGFR) 1/2 moiety with stronger affinity for VEGF than bevacizumab, resulted in antileukemia effects and enhanced the efficacy of systemic chemotherapy. The efficacy of aflibercept alone and in combination with doxorubicin was evaluated in human VEGF-expressing acute myeloid leukemia (AML) cell lines and primary cells xenotransplanted into immunodeficient mic… Show more
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