Abstract:<div>Abstract<p><b>Purpose:</b> Little is known about the optimal clinical use of ABT-888 (veliparib) for treatment of glioblastoma. ABT-888 is a PARP inhibitor undergoing extensive clinical evaluation in glioblastoma, because it may synergize with the standard-of-care temozolomide (TMZ). We have elucidated important factors controlling ABT-888 efficacy in glioblastoma.</p><p><b>Experimental Design:</b> We used genetically engineered spontaneous glioblastoma mous… Show more
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