Data for evolutive analysis of insulin related peptides in bilaterian species

Abstract

In bilaterian species, the amino acid sequence conservation between Insulin related peptides is relatively low except for the cysteine residues involved in the disulphide bonds. In the A chain, the conserved cystein residues are included in a signature motif. Investigating the variations in this motif would give insight into the phylogenetic history of the family. The table presented in this paper contains a large set of insulin-related peptides in bilateral phylogenetic groups (deuterostomian, ecdysozoan, lophotrochozoan). NCBI databases in silico wide screening combined with bibliographic researches provided a framework for identifying and categorising the structural characteristics of these insulin related peptides. The dataset includes NCBI IDs of each sequence with hyperlinks to FASTA format. Moreover, the structural type (α, β or γ), the A chain motif, the total number of cysteins, the C peptide cleavage mode and the potential additional domains (D or E) are specified for each sequence. The data are associated with the research article “Molecular evolution and functional characterisation of insulin-related peptides in molluscs: contributions of Crassostrea gigas genomic and transcriptomic-wide screening” [1]. The table presented here can be found at http://dx.doi.org/10.17632/w4gr8zcpk5.4#file-21c0f6a5-a3e3-4a15-86e0-e5a696458866.

The slowly evolving genome of the xenacoelomorph wormXenoturbella bocki

“…Bilaterian prokineticin-like sequences were searched in ncbi nucleotide, EST and SRA databases as well as in the Saccoglossus kowalevskii genome assembly 74,98 ( groups.oist.jp/molgenu ) using various bilaterian prokineticin-related protein sequences as query. Sequences used for alignments shown in figures were collected from ncbi nucleotide and protein databases as well as from the following publications: 7B2 46 ; NucB2 92 ; Insulin 99 ; Prokineticin 37,38,100 . Alignments for figures were created with Jalview (jalview.org).…”

Transcriptome Profiling of the Pacific Oyster Crassostrea gigas Visceral Ganglia over a Reproduction Cycle Identifies Novel Regulatory Peptides

“…In mollusks—a major representative phylum of Lophotrochozoa—the repertoire of NPs is now well characterized based on the interplay between genome/transcriptome mining approaches and mass spectrometry identification of mature NPs in the main class-level taxa, including Gastropoda [ 15 , 16 , 17 , 18 ], Cephalopoda [ 19 ], Bivalvia [ 20 , 21 ], as well as other taxa [ 22 ]. In C. gigas , a variety of neuropeptide precursors (NPPs)/peptide precursors (PPs) has been identified thanks to the mining of genomic and transcriptomic resources [ 20 , 23 , 24 , 25 , 26 ]. These works also led to the functional characterization of specific NP signaling systems involved in feeding [ 27 , 28 ], as well as in the regulation of water and ionic balance [ 29 , 30 ] and energy storage [ 31 ].…”