Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML
Ataur Katebi,
Xiaowen Chen,
Daniel Ramirez
et al.
Abstract:Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of poorly differentiated myeloid cells, with a heterogenous mutational landscape. Mutations in IDH1 and IDH2 are found in 20% of the AML cases. Although much effort has been made to identify genes associated with leukemogenesis, the regulatory mechanism of AML state transition is still not fully understood. To alleviate this issue, here we develop a new computational approach that integrates genomic data from diverse sources, including… Show more
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