Data-driven desirability function to measure patients’ disease progression in a longitudinal study

Chen, Hsiu-Wen; Wong, Weng Kee; Xu, Hongquan

doi:10.1080/02664763.2015.1077378

Cited by 2 publications

(5 citation statements)

References 22 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another advantage of the q‐FP methodology is that it provides a quantitative result along a continuous numerical scale using the desirability functions used in this study. Such functions have been used as quality assessment tools in industry and are now beginning to be evaluated in medical contexts . The extended dynamic range may allow assessment of more nuanced changes in fibrosis that may not be captured by traditional scales given their limited range of measurement.…”

Section: Discussionsupporting

confidence: 83%

“…Such functions have been used as quality assessment tools in industry and are now beginning to be evaluated in medical contexts. (21,25) The extended dynamic range may allow assessment of more nuanced changes in fibrosis that may not be captured by traditional scales given their limited range Table S7 for further details regarding these data. of measurement.…”

Section: Discussionmentioning

confidence: 99%

“…This thus provided a composite desirability index with an infinite scale for measurement of dynamic changes in fibrosis. Interested readers are also referred to detailed reviews of this methodology for the mathematical background and validity of this approach …”

Section: Methodsmentioning

confidence: 99%

“…Interested readers are also referred to detailed reviews of this methodology for the mathematical background and validity of this approach. (20,21)…”

Section: Extending the Dynamic Scale Of Measurement By A Linearized Smentioning

confidence: 99%

See 3 more Smart Citations

Dual‐photon microscopy‐based quantitation of fibrosis‐related parameters (q‐FP) to model disease progression in steatohepatitis

et al. 2017

View full text Add to dashboard Cite

There is a need for further refinement of current histological systems for assessment of hepatic fibrosis in nonalcoholic fatty liver disease (NAFLD). This study evaluated hepatic fibrosis in NAFLD using dual photon microscopy based quantitation of fibrosis-related parameters (q-FPs). Fifty (test cohort) and 42 (validation cohort) subjects with NAFLD and the full spectrum of fibrosis were studied. Q-FPs were measured in specific predefined regions of interest (general, vessel, perisinusoid and vascular septa). Seventy q-FPs had inter- and intra-observer concordance ≥0.8 and were related to the NASH CRN fibrosis staging. Of these, 16 q-FPs with the strongest correlations (p<0.001 for all) were entered in a principal component analysis model (Odds ratio [OR] 7.8, p<0.001), which separated any stage of fibrosis versus no fibrosis, and cirrhosis versus earlier stages with the areas under receiver-operating-characteristic curves of 0.88 and 0.93 (p≤0.01 for both), respectively. In an independent multivariable analysis, four q-FPs including the number of collagen strands (OR 8.5, p=0.004), strand length (OR 12.0, p=0.02), strand eccentricity (OR 8.3, p=0.004), and strand solidity (OR 8.0, p=0.003) were independently associated with fibrosis stages and were used to model fibrosis along a continuous linear scale using Desirability functions; this linear scale of fibrosis measurement was also related to fibrosis stage (p < 0.0001). The robustness of both the multivariable model and the linear scale of measurement was confirmed in the validation cohort. Conclusion Q-FPs model provides an accurate reproducible method to evaluate fibrosis in NAFLD along a quantitative and continuous scale.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Interested readers are also referred to detailed reviews of this methodology for the mathematical background and validity of this approach. (20,21)…”

Section: Extending the Dynamic Scale Of Measurement By A Linearized Smentioning

confidence: 99%

See 2 more Smart Citations

Dual‐photon microscopy‐based quantitation of fibrosis‐related parameters (q‐FP) to model disease progression in steatohepatitis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Most current sarcopenia definitions incorporate these three components in a stepwise system, using only a yes/no categorical variable as response. However, desirability functions assess a patient's overall response at once, based on multiple outcome measures [23]. Moreover, the desirability approach allows a continuous and hence more sensitive measurement of overall sarcopenia status.…”

Section: Discussionmentioning

confidence: 99%

Acute sarcopenia changes following hospitalization: influence of pre-admission care dependency level

et al. 2021

View full text Add to dashboard Cite

Introduction Hospitalization is associated with acute changes in sarcopenia status in older people, but the influencing factors are not fully understood. Pre-admission care dependency level as a risk factor has not yet been investigated. Objective Evaluate if pre-admission care dependency level is an independent predictor of sarcopenia changes following hospitalization. Setting and subjects Data came from the Sarcopenia 9+ EAMA Project, a European prospective multi-centre study. For this study, 227 hospitalised older people were included from four different hospitals in Belgium, Spain and Poland, between 18 February 2019 and 5 September 2020. Methods Sarcopenia status at admission and discharge were calculated using a combined score (desirability value) based on muscle mass (calf circumference), strength (grip) and function (walking speed). Ratio of admission to discharge status was the outcome (desirability ratio; 1.00 meaning no difference). Predictor variable was the pre-admission care dependency level, classified into three groups: independent older people living at home, dependent older people living at home and older people living in a care home. Linear regression models were applied, considering potential confounders. Results Mean desirability ratio for dependent older people living at home (‘middle dependent group’) was lower (0.89) compared to independent older people (0.98; regression coefficient −0.09 [95% CI −0.16, −0.02]) and care home patients (1.05; −0.16 [95% CI −0.01, −0.31]). Adjusting for potential confounders or using another statistical approach did not affect the main results. Conclusion Dependent older people living at home were at higher risk of deterioration in sarcopenia status following hospitalization. In-depth studies investigating causes and potential interventions of these findings are needed.

show abstract

Data-driven desirability function to measure patients’ disease progression in a longitudinal study

Cited by 2 publications

References 22 publications

Dual‐photon microscopy‐based quantitation of fibrosis‐related parameters (q‐FP) to model disease progression in steatohepatitis

Dual‐photon microscopy‐based quantitation of fibrosis‐related parameters (q‐FP) to model disease progression in steatohepatitis

Acute sarcopenia changes following hospitalization: influence of pre-admission care dependency level

Contact Info

Product

Resources

About