Data-Driven Classification of Spectral Profiles Reveals Brain Region-Specific Plasticity in Blindness

Lubinus, Christina; Orpella, Joan; Keitel, Anne; Gudi-Mindermann, Helene; Engel, Andreas K.; Roeder, Brigitte; Rimmele, Johanna Maria

doi:10.1093/cercor/bhaa370

Cited by 16 publications

(24 citation statements)

References 160 publications

(252 reference statements)

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“…Auditory spectral profiles turned out to be modulated during auditory processing. Lubinus and colleagues [14] have discovered that visual deprivation is reflected in the modulation of spectral fingerprints, indicating possible correspondence with the structural and functional adaptation of the human brain. Likewise, Mellem with collaborators [6] demonstrated via a similar method that there is a mix of lower and higher frequency peaks across the brain and it does not follow a simple lower order-higher order processing hierarchy.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, spectral profiles' peaks that correspond to the natural frequencies of ROIs [12], [13], are consistently modulated by specific tasks, neurological or mental disorders. They can be generalized across groups of participants [14], [7]. In this paper, we introduce a novel implementation of the Spectral Fingerprinting technique, in a highly configurable MATLAB toolbox.…”

Section: Introductionmentioning

confidence: 99%

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ToFFi -- Toolbox for Frequency-based Fingerprinting of Brain Signals

Komorowski¹,

Rykaczewski²,

Piotrowski³

et al. 2021

Preprint

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Spectral fingerprints (SFs) are unique power spectra signatures of human brain regions of interest (ROIs, Keitel & Gross, 2016). SFs allow for accurate ROI identification and can serve as biomarkers of differences exhibited by non-neurotypical groups. At present, there are no open-source, versatile tools to calculate spectral fingerprints. We have filled this gap by creating a modular, highly-configurable MATLAB Toolbox for Frequency-based Fingerprinting (ToFFi). It can transform MEG/EEG signals into unique spectral representations using ROIs provided by anatomical (AAL, Desikan-Killiany), functional (Schaefer), or other custom volumetric brain parcellations. Toolbox design supports reproducibility and parallel computations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ToFFi -- Toolbox for Frequency-based Fingerprinting of Brain Signals

Komorowski¹,

Rykaczewski²,

Piotrowski³

et al. 2021

Preprint

Self Cite

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“…83 Previous EEG studies in CB and CC individuals have repeatedly observed lower alpha oscillatory activity 51,53,54 and in CB individuals higher gamma oscillatory activity. 55,56 Alpha oscillatory activity has been considered to be an electrophysiological signature for the control of the excitatory/inhibitory (E/I) balance of neural circuits. 84 In the present context, it is important to note that alpha oscillatory activity has been found to inversely correlate with ALFF, [45][46][47]85 while gamma band activity was found in monkeys to positively correlated with slow BOLD fluctuations.…”

Section: Discussionmentioning

confidence: 99%

“…[51][52][53][54] Moreover, two MEG studies later reported enhanced gamma activity in congenitally permanently blind individuals compared to typically sighted controls. 55,56 Recent studies have suggested that alpha and gamma oscillatory activity indicate antagonistic mechanisms with alpha oscillations controlling gamma oscillatory activity. 57,58 Interestingly, in monkeys it has been observed that slow BOLD fluctuations correlated with high frequency local field potentials (LFP) in the gamma range particularly in an eyes closed condition.…”

Section: Introductionmentioning

confidence: 99%

Typical resting state activity of the brain requires visual input during an early sensitive period

Rączy

Hölig

Mjs

et al. 2021

Preprint

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Sensory deprivation, following a total loss of one sensory modality e.g. vision, has been demonstrated to result in intra- and cross-modal plasticity. It is yet not known to which extent intra- and cross-modal plasticity as a consequence of blindness reverse if sight is restored. Here, we used functional magnetic resonance imaging to acquire blood oxygen level dependent (BOLD) resting state activity during an eyes open and an eyes closed state in congenital cataract-reversal individuals, developmental cataract-reversal individuals, congenitally permanently blind individuals and sighted controls. The amplitude of low frequency fluctuations (ALFF) of the BOLD signal - a neural marker of spontaneous brain activity during rest - was analyzed. As has been shown before, in normally sighted controls we observed an increase in ALFF during rest with the eyes open compared to rest with eyes closed in visual association areas and in parietal cortex but a decrease in auditory and sensorimotor regions. In congenital cataract-reversal individuals, we found an increase of the amplitude of slow BOLD fluctuations in visual cortex during rest with eyes open compared to rest with eyes closed too but this increase was larger in amplitude than in normally sighted controls. At the same time, congenital cataract-reversal individuals lagged a similar increase in parietal regions and did not show the typical decrease of ALFF in auditory and sensorimotor cortex. Congenitally blind individuals displayed an overall higher amplitude in slow BOLD fluctuations in visual cortex compared to sighted individuals and compared to congenital cataract-reversal individuals in the eyes closed condition. Higher ALFF in visual cortex of congenital cataract-reversal individuals than in normally sighted controls during eyes open might indicate an altered excitatory-inhibitory balance of visual neural circuits. By contrast, the lower parietal increase and the missing downregulation in auditory and sensorimotor regions suggest a reduced influence of the visual system on multisensory and the remaining sensory systems after restoring sight in congenitally blind individuals. These results demonstrate a crucial dependence of multisensory neural networks on visual experience during a sensitive phase in human brain development.

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“…54–57 Moreover, two magnetoencephalography studies later reported enhanced gamma activity in congenitally permanently blind individuals compared with typically sighted controls. 58 , 59 Recent studies have suggested that alpha and gamma oscillatory activity indicate antagonistic mechanisms with alpha oscillations controlling gamma oscillatory activity. 60 , 61 Interestingly, in monkeys, it has been observed that slow BOLD fluctuations positively correlate with high frequency local field potentials (LFPs) in the gamma range particularly in an EC condition.…”

Section: Introductionmentioning

confidence: 99%

Typical resting-state activity of the brain requires visual input during an early sensitive period

Rączy

Hölig

Guerreiro

et al. 2022

Brain Communications

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Sensory deprivation, following a total loss of one sensory modality e.g. vision, has been demonstrated to result in compensatory plasticity. It is yet not known to which extent neural changes, e.g. higher resting state activity in visual areas (cross-modal plasticity) as a consequence of blindness, reverse, when sight is restored. Here, we used functional MRI to acquire blood oxygen level dependent (BOLD) resting state activity during an eyes open (EO) and an eyes closed (EC) state in congenital cataract-reversal individuals, developmental cataract-reversal individuals, congenitally permanently blind individuals and sighted controls. The amplitude of low frequency fluctuations (ALFF) of the BOLD signal - a neural marker of spontaneous brain activity during rest - was analyzed. In accord with previous reports, in normally sighted controls we observed an increase in ALFF during rest with the EO compared to rest with EC in visual association areas and in parietal cortex but a decrease in auditory and sensorimotor regions. In congenital cataract-reversal individuals, we found an increase of the amplitude of slow BOLD fluctuations in visual cortex during rest with EO compared to rest with EC too but this increase was larger in amplitude than in normally sighted controls. In contrast, congenital cataract-reversal individuals lagged a similar increase in parietal regions and did not show the typical decrease of ALFF in auditory cortex. Congenitally blind individuals displayed an overall higher amplitude in slow BOLD fluctuations in visual cortex compared to sighted individuals and compared to congenital cataract-reversal individuals in the EC condition. Higher ALFF in visual cortex of congenital cataract-reversal individuals than in normally sighted controls during EO might indicate an altered excitatory-inhibitory balance of visual neural circuits. By contrast, the lower parietal increase and the missing downregulation in auditory regions suggest a reduced influence of the visual system on multisensory and the other sensory systems after restoring sight in congenitally blind individuals. These results demonstrate a crucial dependence of visual and multisensory neural system functioning on visual experience during a sensitive phase in human brain development.

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Data-Driven Classification of Spectral Profiles Reveals Brain Region-Specific Plasticity in Blindness

Cited by 16 publications

References 160 publications

ToFFi -- Toolbox for Frequency-based Fingerprinting of Brain Signals

ToFFi -- Toolbox for Frequency-based Fingerprinting of Brain Signals

Typical resting state activity of the brain requires visual input during an early sensitive period

Typical resting-state activity of the brain requires visual input during an early sensitive period

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