Data compatibility in the addiction sciences: An examination of measure commonality

Conway, Kevin P.; Vullo, Genevieve C.; Kennedy, Ashley; Finger, Matthew S.; Agrawal, Arpana; Bjork, James M.; Farrer, Lindsay A.; Hancock, Dana B.; Hussong, Andrea M.; Wakim, Paul; Huggins, Wayne; Hendershot, Tabitha; Nettles, Destiney; Pratt, Joseph; Maiese, Deborah; Junkins, Heather; Ramos, Erin M.; Strader, Lisa; Hamilton, Carol M.; Sher, Kenneth J.

doi:10.1016/j.drugalcdep.2014.04.029

Cited by 34 publications

(36 citation statements)

References 19 publications

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“…The PhenX Real world Implementation and Sharing (RISING) consortium is a significant step forward in the practical application of PhenX measures (49). PhenX publications have been largely focused on implementation of PhenX measures (35, 50-53), including a recent publication on the commonality of findings in different addictive disorders across measures of addiction (54). …”

Section: Introductionmentioning

confidence: 99%

Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders

Kwako

Momenan

Litten

et al. 2016

Biological Psychiatry

304

278

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This paper proposes a heuristic framework for an Addictions Neuroclinical Assessment (ANA) that incorporates key functional domains derived from the neurocircuitry of addiction. We review how addictive disorders (AD) are presently diagnosed, and the need for new neuroclinical measures to differentiate patients who meet clinical criteria for addiction to the same agent while differing in etiology, prognosis and treatment response. The need for a better understanding of the mechanisms provoking and maintaining addiction, as evidenced by the limitations of current treatments and within-diagnosis clinical heterogeneity, is articulated. In addition, recent changes in the nosology of AD, challenges to current classification systems, and prior attempts to subtype individuals with AD are described. Complementary initiatives, including the Research Domain Criteria (RDoC) project, which have established frameworks for the neuroscience of psychiatric disorders, are discussed. Three domains, executive function, incentive salience, and negative emotionality, tied to different phases in the cycle of addiction, form the core functional elements of AD. Measurement of these domains in epidemiologic, genetic, clinical, and treatment studies will provide the underpinnings for an understanding of cross-population and temporal variation in addictions, shared mechanisms in addictive disorders, impact of changing environmental influences, and gene identification. Finally, we show that it is practical to implement such a deep neuroclinical assessment using a combination of neuroimaging and performance measures. Neuroclinical assessment is key to reconceptualizing the nosology of AD on the basis of process and etiology, an advance that can lead to improved prevention and treatment.

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Section: Introductionmentioning

confidence: 99%

Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders

Kwako

Momenan

Litten

et al. 2016

Biological Psychiatry

304

278

View full text Add to dashboard Cite

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“…Recently, several different institutes at NIH have tried to set up common data elements (CDEs) for studies involving human subjects in a particular research domain (Gershon, et al, 2010; Hamilton, et al, 2011; Grinnon, et al, 2013; Conway, et al, 2014, http://www.nlm.nih.gov/cde/). The CDEs are often clinical assessments, but they can include other measurements such as blood pressure (Hamilton et al, 2011).…”

Section: Elements Of An Infrastructure For Sharing Data Related To Comentioning

confidence: 99%

Can data repositories help find effective treatments for complex diseases?

Farber

2017

Progress in Neurobiology

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There are many challenges to developing treatments for complex diseases. This review explores the question of whether it is possible to imagine a data repository that would increase the pace of understanding complex diseases sufficiently well to facilitate the development of effective treatments. First, consideration is given to the amount of data that might be needed for such a data repository and whether the existing data storage infrastructure is enough. Several successful data repositories are then examined to see if they have common characteristics. An area of science where unsuccessful attempts to develop a data infrastructure is then described to see what lessons could be learned for a data repository devoted to complex disease. Then, a variety of issues related to sharing data are discussed. In some of these areas, it is reasonably clear how to move forward. In other areas, there are significant open questions that need to be addressed by all data repositories. Using that baseline information, the question of whether data archives can be effective in understanding a complex disease is explored. The major goal of such a data archive is likely to be identifying biomarkers that define sub-populations of the disease.

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“…The impetus for this project relates to the fact that there is very low commonality in the measures used across studies of abuse and addiction (11). This project, which added 45 measures to the PhenX Toolkit, included a core collection and six specialty collections of SAA measures.…”

Section: Phenx Measures For Substance Abuse and Addiction Researchmentioning

confidence: 99%

“…Existing research clearly documents significant comorbidity of substance use difficulties in individuals who are experiencing mental health related difficulties. Thus, the MHRP recommended including the brief SAA Core: Tier 1 assessments of tobacco, alcohol, and substance use (11) in the NIMH Core: Tier 2, with separate measures for adults and adolescents. The PhenX Toolkit already includes self/parent report measures of life events for children [Adverse Life Events Scale (34,35)] and adults [Traumatic Life Events Questionnaire (36,37)], each of which had originally been selected by the social environments working group.…”

Section: Nimh Core: Tiermentioning

confidence: 99%