Abstract-Industrial Wireless Sensor Networks (IWSNs) are expected to offer promising monitoring solutions to meet the demands of monitoring applications for fault diagnosis in largescale petrochemical plants, however, involves heterogeneity and Big Data problems due to large amounts of sensor data with high volume and velocity. Cloud Computing is an outstanding approach which provides a flexible platform to support the addressing of such heterogeneous and data-intensive problems with massive computing, storage, and data-based services. In this paper, we propose a Cloud-based Data-intensive Framework (CDF) for on-line equipment fault diagnosis system that facilitates the integration and processing of mass sensor data generated from Industrial Sensing Ecosystem (ISE). ISE enables data collection of interest with topic-specific industrial monitoring systems. Moreover, this approach contributes the establishment of on-line fault diagnosis monitoring system with sensor streaming computing and storage paradigms based on Hadoop as a key to the complex problems. Finally, we present a practical illustration referred to this framework serving equipment fault diagnosis systems with the ISE.