In this paper, we develop, analyze, and test new position and orientation (or pose) estimation and integrity monitoring methods using data from light detection and ranging (lidar) and an inertial measurement unit (IMU). Testing is performed in a mapped laboratory environment.This research is intended for safety evaluation in autonomous vehicles such as automated driving systems (ADSs). ADS testing is necessary but insufficient to provide navigation safety guarantees because accumulating "autonomously driven" road miles does not provide a statistically significant number of traveled miles as compared with manned driving incidents (Kalra & Groves, 2017;Kalra & Paddock, 2016).To quantify safety risks in ADS navigation, we leverage prior analytical work in global navigation satellite system (GNSS)-based aviation navigation, where safety is assessed in terms of integrity. Integrity is a measure of trust in sensor information (International Civil Aviation Organization, 2006). Several methods have been established to predict aircraft GNSS integrity risk (Radio Technical Commission for Aeronautics (RTCA) Special Committee 159, 1996; Working Group C, 2016).