Data‐ and theory‐driven approaches for understanding paths of epithelial–mesenchymal transition
Tian Hong,
Jianhua Xing
Abstract:SummaryReversible transitions between epithelial and mesenchymal cell states are a crucial form of epithelial plasticity for development and disease progression. Recent experimental data and mechanistic models showed multiple intermediate epithelial–mesenchymal transition (EMT) states as well as trajectories of EMT underpinned by complex gene regulatory networks. In this review, we summarize recent progress in quantifying EMT and characterizing EMT paths with computational methods and quantitative experiments … Show more
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