DAT1 polymorphism associated with poor decision‐making in males with antisocial personality disorder and high psychopathic traits

Rafiei, Dorsa; Kolla, Nathan J.

doi:10.1002/bsl.2537

Cited by 3 publications

(6 citation statements)

References 68 publications

(75 reference statements)

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“…Interestingly, the endogenous opioid system has recently been linked to several reward-related antisocial behaviors (e.g., manipulativeness), substance use, and sensation-seeking ( 74 , 75 ), which supports our results regarding Deceitfulness and LPE symptoms. Overall, our results provide evidence of how different neurotransmitter systems may play prominent roles in the emergence of antisocial behaviors ( 14 – 16 ). Despite that the emphasis in literature is being mainly placed on dopaminergic and serotoninergic systems, the relationship between the opioid system and antisocial behaviors warrants further investigation.…”

Section: Discussionmentioning

confidence: 60%

“…Through a meta-analysis of resting-state connectivity studies in antisocial population, we also showed evidence that both amygdala and mPFC (i.e., ventral and dorsal) exhibited disrupted connectivity ( 12 ). Moreover, there is a growing body of evidence suggesting the importance of serotoninergic [mainly serotonin transporter (5-HTT) and 5-HT 2A and 5-HT 2B receptors] and dopaminergic systems [mainly Dopamine transporter (DAT) and D 2 and D 4 receptors] in our comprehension of antisocial behaviors ( 13 – 16 ). Indeed, these systems are known to encompass the amygdala/ATL and mPFC (e.g., mesolimbic/mesocortical dopaminergic pathways) ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

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The origins of evil: From lesions to the functional architecture of the antisocial brain

Dugré

Potvin²

2022

Front. Psychiatry

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In the past decades, a growing body of evidence has suggested that some individuals may exhibit antisocial behaviors following brain lesions. Recently, some authors have shown that lesions underpinning antisocial behaviors may disrupt a particular brain network during resting-state. However, it remains unknown whether these brain lesions may alter specific mental processes during tasks. Therefore, we conducted meta-analytic co-activation analyses on lesion masks of 17 individuals who acquired antisocial behaviors following their brain lesions. Each lesion mask was used as a seed of interest to examine their aberrant co-activation network using a database of 143 whole-brain neuroimaging studies on antisocial behaviors (n = 5,913 subjects). We aimed to map the lesion brain network that shows deficient activity in antisocial population against a null distribution derived from 655 control lesions. We further characterized the lesion-based meta-analytic network using term-based decoding (Neurosynth) as well as receptor/transporter density maps (JuSpace). We found that the lesion meta-analytic network included the amygdala, orbitofrontal cortex, ventro- and dorso-medial prefrontal cortex, fusiform face area, and supplementary motor area (SMA), which correlated mainly with emotional face processing and serotoninergic system (5-HT1A and 5-HTT). We also investigated the heterogeneity in co-activation networks through data-driven methods and found that lesions could be grouped in four main networks, encompassing emotional face processing, general emotion processing, and reward processing. Our study shows that the heterogeneous brain lesions underpinning antisocial behaviors may disrupt specific mental processes, which further increases the risk for distinct antisocial symptoms. It also highlights the importance and complexity of studying brain lesions in relationship with antisocial behaviors.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

The origins of evil: From lesions to the functional architecture of the antisocial brain

Dugré

Potvin²

2022

Front. Psychiatry

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“…Many researchers believe that the cause of ASPD is a developmental abnormality of the nervous system 43 . Rafiei and Kolla 44 used the Iowa Gambling Task (IGT) and positron emission tomography to confirm abnormalities in the dopaminergic system in ASPD patients. The dopamine transporter gene (DAT1) was related to decision‐making, and ASPD patients with low DAT1 genotype activity performed remarkably worse on the IGT.…”

Section: Discussionmentioning

confidence: 99%

“…The dopamine transporter gene (DAT1) was related to decision‐making, and ASPD patients with low DAT1 genotype activity performed remarkably worse on the IGT. Lower DAT activity was reflected in lower DA reuptake and increased synaptic concentrations of DA 44 . Also, the DAT1 gene interacts with the social environment and drug use to further influence the neural activity of ASPD patients 44 .…”

Section: Discussionmentioning

confidence: 99%

“…Lower DAT activity was reflected in lower DA reuptake and increased synaptic concentrations of DA. 44 Also, the DAT1 gene interacts with the social environment and drug use to further influence the neural activity of ASPD patients. 44 Therefore, we hypothesize that ASPD patients have more severe DA abnormalities than non-ASPD patients and require a longer length of abstinence to recover.…”

Section: Prevalence Demographic and Clinical Characteristics Of Aspd ...mentioning

confidence: 99%

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Prevalence, demographics, and clinical correlates of antisocial personality disorder in Chinese methamphetamine patients

Tian

Fan³

et al. 2022

American J Addict

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Background and Objectives: Antisocial personality disorder (ASPD) is very common among methamphetamine (MA) patients, but very few studies have been conducted in China. This study aimed to investigate the prevalence and clinical correlates of ASPD among Chinese MA patients. Methods: We recruited 627 MA patients and collected demographic and MA use data through one-on-one semi-structured interviews. ASPD was measured by the Mini International Neuropsychiatric Interview (M.I.N.I.). The Desires for Drug Questionnaire (DDQ) and visual analog scale (VAS) were used to assess drug cravings.Results: The prevalence rate of ASPD among MA patients was 27.59% (173/627).Patients with ASPD had greater age at the first onset, duration of MA use, length of abstinence, VAS, DDQ desire and intention, negative reinforcement, and total DDQ scores than patients without ASPD. Stepwise binary logistic regression analysis revealed that age, age at the first onset, length of abstinence, and DDQ-negative reinforcement were independently associated with ASPD in MA patients.Discussion and Conclusions: Our findings suggest that the prevalence of ASPD is high among Chinese MA patients. Furthermore, some demographic and clinical variables are associated with ASPD in MA patients.Scientific Significance: We focused our study on the clinical profile of ASPD and the reasons for its high prevalence in Chinese methamphetamine patients. We identified several demographic and clinical variables as correlates of the occurrence of ASPD in methamphetamine patients, which provides evidence for ASPD comorbidity in methamphetamine patients.

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Psychopathology of antisocial personality disorder: from the structural, functional and biochemical perspectives

Wong

2023

Egypt J Neurol Psychiatry Neurosurg

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Background Antisocial personality disorder (ASPD) is characterized by a lack of empathy, a sense of guiltlessness and shamelessness, as well as impulsiveness. ASPD is a relatively common psychiatric condition in the general population, whereas individuals with ASPD often have substantial social impairments and a lower quality of life, especially for those who have mental comorbidities. This review gives an overview of the etiological and clinical aspects of ASPD and critically examines ASPD from the structural, functional and biochemical perspectives. Results Twin and family studies showed genetic predisposition in ASPD. Some candidate genes associated with ASPD include SLC6A4, COMT, 5-HTR2A, TPH1, DRD2, OXTR, CACNG8, COL25A1 and several serotonergic genes. Environmental factors like adverse childhood experience (ACE) and active empathy deficits in toddlerhood play a role in the etiology of ASPD, whereas low intelligence or attainment, a large family size, a convicted parent, a disrupted family, and a young mother are predictors of antisocial personality. Structural abnormalities involving the corpus callosum, amygdala, putamen, anterior cingulate cortex, as well as orbitofrontal- and dorsolateral frontal cortices have been identified in ASPD. Other observed structural changes include a decrease in grey matter volume, whole-brain volume, and white matter volume and thickness. In addition, functional abnormalities involving autonomic activity, prefrontal functions, as well as brain functional networks like sensorimotor networks, cognitive networks and cortico-striatal connectivity have been reported. Biochemical factors associated with ASPD include fatty acid amide hydrolase (FAAH) reduction in the amygdala, as well as changes in plasma levels of inflammatory biomarkers and neurotropic factors [namely, tumor necrosis factor (TNF)-α, interleukin 10 (IL-10), transforming growth factor (TGF)-β1 and brain-derived neurotrophic factor (BNDF). Increased plasma levels of testosterone, ghrelin and cortisol and decreased levels of leptin have also been implicated in ASPD. Conclusions To date, there is no Food and Drug Administration (FDA) approved drugs for ASPD. Understanding the disease from different perspectives is important, as this provides insights into the underlying mechanisms of ASPD, whereas the associated biochemical markers can be used as potential diagnostic and treatment targets for ASPD.

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DAT1 polymorphism associated with poor decision‐making in males with antisocial personality disorder and high psychopathic traits

Cited by 3 publications

References 68 publications

The origins of evil: From lesions to the functional architecture of the antisocial brain

The origins of evil: From lesions to the functional architecture of the antisocial brain

Prevalence, demographics, and clinical correlates of antisocial personality disorder in Chinese methamphetamine patients

Psychopathology of antisocial personality disorder: from the structural, functional and biochemical perspectives

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