Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension

Phan, Carole; Seferian, Andrei; Huertas, Alice; Tu, Ly; Thuillet, Raphaël; Sattler, Caroline; Hiress, Morane Le; Tamura, Yuichi; Jutant, Étienne-Marie; Chaumais, Marie‐Camille; Bouchet, Stéphane; Manéglier, Benjamin; Molimard, Mathiéu; Rousselot, Philippe; Sitbon, Olivier; Simonneau, Gérald; Montani, David; Humbert, Marc; Guignabert, Christophe

doi:10.1183/13993003.congress-2016.oa262

Cited by 1 publication

(1 citation statement)

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“…The resultant hypoxia deteriorated lung perfusion and exacerbated oxygen shortage. 76 Other than oxygen tension, activation of resident cells or inflammatory cells also depletes the antioxidant capacity of the lungs leading to organ injury. 77 , 78 Another explanation for the occurrence of severe forms of COVID-19 in aged subjects may be related to superoxide dismutase-3 and activating transcription factor-4, the components of the lung antioxidant system, that are not efficacious in old people.…”

Section: Endothelial Dysfunction and Thrombosismentioning

confidence: 99%

Is It All About Endothelial Dysfunction and Thrombosis Formation? The Secret of COVID-19

Elyaspour

Zibaeenezhad

Razmkhah

et al. 2021

Clin Appl Thromb Hemost

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The world is in a hard battle against COVID-19. Endothelial cells are among the most critical targets of SARS-CoV-2. Dysfunction of endothelium leads to vascular injury following by coagulopathies and thrombotic conditions in the vital organs increasing the risk of life-threatening events. Growing evidences revealed that endothelial dysfunction and consequent thrombotic conditions are associated with the severity of outcomes. It is not yet fully clear that these devastating sequels originate directly from the virus or a side effect of virus-induced cytokine storm. Due to endothelial dysfunction, plasma levels of some biomarkers are changed and relevant clinical manifestations appear as well. Stabilization of endothelial integrity and supporting its function are among the promising therapeutic strategies. Other than respiratory, COVID-19 could be called a systemic vascular disease and this aspect should be scrutinized in more detail in order to reduce related mortality. In the present investigation, the effects of COVID-19 on endothelial function and thrombosis formation are discussed. In this regard, critical players, laboratory findings, clinical manifestation, and suggestive therapies are presented.

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Section: Endothelial Dysfunction and Thrombosismentioning

confidence: 99%