Das Verhalten der Herzfrequenz gesunder Menschen beim Übergang vom Liegen zum Stehen

Drischel, H; Fanter, H.; Gürtler, H; Labitzke, H.; Priegnitz, F.

doi:10.1007/bf02119649

Cited by 19 publications

(8 citation statements)

References 18 publications

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“…However, this idea does not fit with the generally accepted idea that in man during exercise blood pressure increases (Freyschuss, 1970;Rowell er al., 1981;Mitchell & Schmidt, 1983). Furthermore, none of those studies (Drischel et al, 1963;Borst et al, 1982Borst et al, ,1984 dealt with the influence of respiration on the circulatry responses to changes in posture although it is known that respiration can have profound effects on cardiovascular mechanics (de Burgh Daly et al, 1967;Melcher, 1976;Eckberg et al, 1980). Therefore our interest in this study has focused on two main questions:…”

Section: Introductionmentioning

confidence: 99%

Circulatory responses to stand up: discrimination between the effects of respiration, orthostasis and exercise

Sprangers

Lieshout

Karemaker

et al. 1991

Clinical Physiology

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The initial circulatory responses to an active change in posture (stand up from supine) were compared with the responses induced by a passive change in posture (head-up tilt) and a burst of muscular exercise on a bicycle ergometer (upright cycling) in order to differentiate between exercise- and orthostasis-induced effects. In eight subjects heart rate responses and in four subjects intra-arterial pressure transients were measured. In addition the effects of respiration on heart rate responses to the three manoeuvres were assessed. Both stand up and cycling induced almost superimposable and pronounced heart rate responses lasting for about 30 s. This contrasts with the more gradual increases following head-up tilt. Changing the respiratory phase during the performance of the manoeuvres exerted its effect on heart rate responses in the first 5 s only. Like stand up, cycling induced a transient blood pressure fall lasting for 30 s on average. As both manoeuvres were performed during inspiration the transients observed are not caused by involuntary Valsalva straining. In conclusion, the maximum and duration of the heart rate responses induced by stand up, cycling and head-up tilt are not influenced by respiratory activity. The initial fall in blood pressure following stand up is probably the result of the muscular effort of the manoeuvre and not due to the effects of orthostasis or Valsalva straining.

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Section: Introductionmentioning

confidence: 99%

Circulatory responses to stand up: discrimination between the effects of respiration, orthostasis and exercise

Sprangers

Lieshout

Karemaker

et al. 1991

Clinical Physiology

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“…During the first 30 sec of standing a sharp rise of heart rate takes place and after 6-10 min the pulse seems to stabilize [4] (fig. 2).…”

Section: Orthostatic Testsmentioning

confidence: 99%

“…In addition to this primary neurogenic form there are a number of secondary neurogenic disturbances which include various types of neurop athies due to metabolic (diabetes, porphyruria, amyloidosis, pernicious anemia) or anatomic lesions (syringomyelia) [4,21].…”

Section: Different Types Of Hypotensionmentioning

confidence: 99%

Pathophysiological Classification and Diagnosis of Orthostatic Hypotension

Thulesius¹

1976

Cardiology

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“…These changes are relatively consistent after 2 min. of standing (Drischel et al 1963;de MarCes 1976). The normal pattern of orthostatic response was retained also after enprofylline although the highest intravenous dose and the two highest oral doses tended to augment the heart rate increase and systolic blood pressure decrease.…”

Section: Discussionmentioning

confidence: 99%

Tolerance and some Circulatory Effects of Intravenous and Oral Enprofylline in Healthy Volunteers

Lunell

Andersson

Persson

1983

Acta Pharmacologica et Toxicologica

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Enprofylline (3‐propylxanthine), a novel bronchodilating xanthine derivative that seems to lack adenosine antagonistic potency was given intravenously to eight recumbent healthy male volunteers in the doses 0.5, 1 and 1.5 mg/kg body‐weight and to six of them also orally in the doses 2,4 and 6 mg/kg. Mean enprofylline plasma levels ranged between 1.6 and 4.4 mg/l (8.2–22.2 μmol/l) after intravenous, and between 1.9 and 5.5 mg/l (9.8–27.9 μmol/l) after oral adminstration. Enprofylline was rapidly and completely absorbed and had an elimination half‐life of approximately 2 hrs. About 90% of the dose given by either route was recovered as unchanged drug in the urine. A slight but significant increase in heart rate was seen at peak plasma levels after each of the highest intravenous and oral doses. At these dose levels the heart rate response to orthostatic tests was significantly increased by enprofylline. Adverse reactions were mild and short‐lasting and occurred most frequently after the two highest intravenous and oral doses. Headache and nausea were noted in 5 of the 24 intravenous experiments and in 9 of the 17 times that enprofylline was given orally. In conclusion, the circulatory effects of enprofylline were small and the adverse reactions mild. Further clinical studies with enprofylline seem warranted.

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Das Verhalten der Herzfrequenz gesunder Menschen beim Übergang vom Liegen zum Stehen

Cited by 19 publications

References 18 publications

Circulatory responses to stand up: discrimination between the effects of respiration, orthostasis and exercise

Circulatory responses to stand up: discrimination between the effects of respiration, orthostasis and exercise

Pathophysiological Classification and Diagnosis of Orthostatic Hypotension

Tolerance and some Circulatory Effects of Intravenous and Oral Enprofylline in Healthy Volunteers

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